Abstract: The persistent infection of HPV is a risk factor of cervical lesions. The local humoral immunity and cellular immunity are the first defense against the viral infection and disease progression during the cervical infection of HPV and cervical lesions, which is related to the pathogenesis and progression of tumor. The local cellular immune plays main roles in antiviral and inhibition of viral replication, while the local humoral immunity has an important synergistic effect. The vaginal local humoral immune and cellular immune function are changed by HPV infection before and after treatment of cervical lesions, suggesting that the local immune function could be a marker of the HPV outcome and the prognosis of cervical lesions. It is necessary to study whether it is possible to improve the immune function as the adjuvant prevention and treatment of cervical lesions. We discussed here the vaginal local immune function, and the HPV outcomes, in those patients with cervical lesions after treatment.

Key words: Uterine cervical diseases, Papillomavirus infections, Immunity, cellular, Antibody formation