国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2010, Vol. 29 ›› Issue (4): 281-284.

• 综述 • 上一篇    下一篇

辅助生殖技术出生儿童的结局和生长发育情况

许定飞,伍琼芳   

  1. 330006 南昌大学医学院研究生院（许定飞）；江西 省妇幼保健院生殖中心（伍琼芳）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-07-15 发布日期:2010-07-15
  • 通讯作者: 伍琼芳

The Outcome and Growth of Children Born after ART

XU Ding-fei，WU Qiong-fang   

  1. Medical College of Nanchang University （XU Ding-fei）；Reproductive Center of Maternal and Child Health Care Hospital of Jiangxi Province, Nanchang 330006，China（WU Qiong-fang）
  • Received:1900-01-01 Revised:1900-01-01 Published:2010-07-15 Online:2010-07-15
  • Contact: WU Qiong-fang

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摘要： 随着各种辅助生殖技术（ART）的开展，世界范围内通过体外受精- 胚胎移植（IVF-ET）
技术分娩的婴儿日益增加。这些通过助孕技术出生儿童的生长发育情况、ART 的短期及长期安全性已成
为生殖领域专家、人口学家、儿科专家和患者迫切关注的问题。回顾十余年关于助孕技术出生子代安全性
的相关文献，总结通过IVF-ET、胞浆内单精子注射（ICSI）助孕出生的不同年龄段儿童的结局和生长发育
情况。资料表明，ART 出生儿童的生长发育基本上无明显差异，技术本身可能对出生结局并无明显影响。
但是ICSI 儿童的畸形率问题仍存在争议。

关键词: 生殖技术, 辅助, 受精, 体外, 胚胎移植, 精子注射, 细胞质内, 儿童发育, 婴儿, 新生, 儿 童, 学龄前（2~5）, 儿童, 青少年（13~18）, 安全

Abstract: With the development of ART（assisted reproductive technology），many infertile couples get
their babies with the help of the technology. The infant birth through IVF鄄ET（in vitro fertilization and embryo
transfer）shows increasing worldwide. The growth and development of these babies, the short鄄term and long鄄
term safety of ART is also become an important issue which urgently attentioned by experts in the field of
reproductive, demographers, pediatrician, patient and so on.The paper reviews the most relevant literatures on
the issue over the past 10 years. It summaried the birth outcomes and the growth and development for children
of different ages who born through IVF鄄ET and ICSI. The present data show that growth and development of
children born of assisted reproductive technology is basically no difference. The ART technology itself may be
no significant impact on birth outcomes. However, the abnormal rate of ICSI children is still controversial

Key words: Reproductive techniques, assisted, Fertilization in vitro, Embryo transfer, Sperm injections, intracytoplasmic, Child development, Infant, newborn, Child pre（2-5）, Child, Adolesc（13-18）, Safety