国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2010, Vol. 29 ›› Issue (4): 285-287.

• 综述 • 上一篇    下一篇

精子DNA损伤与辅助生殖技术结局

袁韦娜,姜宏   

  1. 230031 合肥，安徽医科大学解放军临床学院生殖 中心
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-07-15 发布日期:2010-07-15
  • 通讯作者: 姜宏

Sperm DNA Damage and the Outcomes of Assisted Reproductive Technology

YUAN Wei-na，JIANG Hong   

  1. Reproductive Medicine Center，the 105th Hospital of PLA Affiliated Anhui Medical University，Hefei 230031，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2010-07-15 Online:2010-07-15
  • Contact: JIANG Hong

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摘要： 精子DNA损伤发生的机制包括染色质包装异常、氧化应激和细胞凋亡等。此外，冷冻保
存和体外制备技术均能影响精子DNA的完整性。精子DNA损伤与精液参数、精子的受精能力和受精后
的胚胎发育潜能、辅助生殖技术（ART）结局及后代遗传风险密切相关。对近年有关精子DNA 损伤的机
制、冷冻保存和精子制备、精子DNA 损伤与精液参数及其与ART结局关系的相关文献进行综述。

关键词: 生殖技术, 辅助, 精子, DNA 损伤, 精液保存, 低温保存, 妊娠结局

Abstract: It has been demonstated that sperm DNA integrity，mainly caused by oxidative stress，
abnormal package of chromatin and abortive apoptosis，have a negative relationship with some semen
evaluation parameters such as concentration，motility and morphology，and could affect the potential of
fertilization and embryonic development，the outcomes of assisted reproductive technology，and increase the
risk of genetic disease for off鄄spring. Cryopreservation of human spermatozoa and sperm preparation techniques
can influence the integrity of sperm DNA. This article briefly reviews the mechanism of sperm DNA damage，
cryopreservation，sperm preparation techniques and the relationship of sperm DNA damage and ART.

Key words: Reproductive techniques, assisted, Sperm, DNA damage, Semen preservation, Cryop鄄 reservation, Pregnancy outcome