国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2010, Vol. 29 ›› Issue (5): 349-352.

• 综述 • 上一篇    下一篇

遗传因素在不明原因复发性流产中的作用

吕兴钰,蔡霞   

  1. 830054乌鲁木齐，新疆医科大学第一附属医院生殖 助孕中心
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-09-15 发布日期:2010-09-15

Hereditary Factor of Unexplained Recurrent Spontaneous Abortion

Lu Xing-yu，CAI Xia.   

  1. The Reproductive Center of the First Affiliated Hospital of Xinjiang Medical University，哉则怎皂择蚤830054，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2010-09-15 Online:2010-09-15

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摘要： 不明原因复发性流产（URSA）是多基因控制的复杂疾病，发生率约占复发性流产的
50%。近年大量研究表明，URSA 与基因多态性有密切的关系，免疫系统中人类白细胞抗原（HLA）、细胞因
子基因多态性；遗传性易栓症相关基因纤溶酶原激活抑制物（PAI-1）、V 因子、人类亚甲基四氢叶酸还原
酶（MTHFR）及载脂蛋白等基因多态性均与URSA 有关；另外，孕激素受体（PR）、胰岛素生长因子等基因
多态性也与URSA 有关。因此，从基因水平上阐明URSA的发病机制，给临床预防、治疗和预后提供指导，
是目前URSA 病因学研究的热点。

关键词: 流产, 习惯性, 多态性, 单核苷酸, 免疫系统, 血栓栓塞, 遗传性易栓症

Abstract: Unexplained recurrent spontaneous abortion （哉砸杂粤）is a complex disease controlled by
various genes. The occurrence of URSA is estimted as 50% of recurrent spontaneous abortion（RSA）. 砸ecently,
many studys indicate that there are compact association between URSA and gene polymorphisms. There are
association between URSA and human leucocyte antigen （匀蕴粤）of immune system and 糟藻造枣葬糟贼燥则早藻灶藻
责燥造赠皂燥则责澡蚤泽皂泽, 蚤灶澡藻则蚤贼藻凿贼澡则燥皂遭燥责澡蚤造蚤葬糟燥则则藻造葬贼藻凿早藻灶藻责造葬泽皂蚤灶燥早藻灶葬糟贼蚤增葬贼燥则蚤灶澡蚤遭蚤贼燥则（孕粤陨原员），灾枣葬糟贼燥则，
m藻贼澡赠造藻灶藻贼藻贼则葬澡赠凿则燥枣燥造葬贼藻则藻凿怎糟贼葬泽藻（酝栽匀云砸）葬灶凿葬责燥造蚤责燥责则燥贼藻蚤灶，责则燥早藻泽贼藻则燥灶藻则藻糟藻责贼燥则（孕砸）and insulin鄄like
growth factor gene polymorphisms. It’s pathogenesis is illuminated at the gene level，which will guide clinical
prevention, therapy and prognosis. Today, the survey on URSA is becoming hot spot increasingly. This text will
overview these correlated surveys in recent years.

Key words: Abortion, habitual, Polymorphisms, single nucleotide, Immune system, Thromboembolism, Inherited thrombophilia