国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2011, Vol. 30 ›› Issue (2): 95-98.

• 综述 • 上一篇    下一篇

基因芯片筛查子宫内膜容受性相关基因的应用

宋晓雯, 赵晓明   

  1. 200001 上海交通大学医学院附属仁济医院生殖医学科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2011-03-15 发布日期:2011-03-15
  • 通讯作者: 赵晓明

Application of Gene Chip in Investigating Genes Associated with Endometrial Receptivity

SONG Xiao-wen， ZHAO Xiao-ming   

  1. Reproductive Medical Center， Shanghai Renji Hospital of Shanghai Jiao Tong University， Shanghai 200001， China
  • Received:1900-01-01 Revised:1900-01-01 Published:2011-03-15 Online:2011-03-15
  • Contact: ZHAO Xiao-ming

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摘要： 胚胎的顺利着床有赖于子宫内膜对其具有良好的容受能力。深入了解子宫内膜容受性的变化，对确定胚胎移植的时机和提高胚胎种植率具有极其重要的意义。新近发展的基因芯片技术可同时检测同一细胞或组织的大量基因，为研究正常或异常内膜的基因变化及其复杂的内在联系提供了高效的途径。综述基因芯片技术在内膜容受性候选基因的筛查、控制性卵巢刺激及不孕相关疾病对内膜容受性相关基因的影响中的应用。

关键词: 子宫内膜容受性, 基因, 芯片分析技术, 寡核苷酸序列分析, 不育, 女（雌）性

Abstract: A successful blastocyst implantation is depend on a receptive endometrium. It is very important to investigate the changes of the endometrial receptivity for determining the time of embryo transplantation and increasing the embryo implatation rate. Gene chip can simultaneously measure the abundance of thousands of DNA or RNA transcripts within cells or tissues to be measured simultaneously. It provides a highefficient approach to understanding changes of many genes and complex interactions, comparing healthy control and disease states. In this review, we discussed the application of gene chip in detection of candidate genes of endometrial receptivity, and investigation of those genes differently expressed in COS therapy or infertility.

Key words: Endometrial receptivity, Genes, Microchip analytical procedures, Oligonucleotide array sequence analysis, Infertility, female