国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2012, Vol. 31 ›› Issue (2): 93-96.

• 论著 • 上一篇    下一篇

喹喃克林女性非手术绝育的临床研究


陆卫群,朱江,邹素萍,刘光华,侯永华,杨正品,肖诗文,安文师,田应梅   

  1. 550025贵州大学人口研究中心（陆卫群）；贵州省人口计生科研所（朱江）；花溪区计生妇幼保健服务中心（邹素萍）；贵阳市南明区计划生育宣传指导站（刘光华）；榕江县计划生育宣传技术站（侯永华）；黎平县计划生育宣传技术指导站（杨正品）；遵义县人口和计划生育妇幼保健院（肖诗文）；凤冈县计生妇幼保健站（安文师）；余庆县计划生育生殖妇幼保健中心（田应梅）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2012-03-15 发布日期:2012-03-15
  • 通讯作者: 朱江

Clinical Study of Quinacrine Female Voluntary Non -Surgical Sterilization

LU Wei -qun，ZHU Jiang， ZOU Su-ping，LIU Guang-hua，HOU Yong-hua，YANG Zheng-pin，XIAO Shi-wen，AN Wen-shi，TIAN Ying-mei   

  1. Center for Research on Population, Guizhou University，Guiyang 550025，China（LU Wei-qun）；Guizhou Provincial Research Institue for Family Planning, Guiyang 550004, China（ZHU Jiang）；Huaxi Health Care Service Center of Maternal and Child, Guiyang 550025，China（ZOU Su -ping）；Nanming Family Planning Station, Guiyang 550001, China（LIU Guang -hua）；Rongjiang County Family Planning Station, Rongjiang County 557200,Guizhou Province, China（HOU Yong-hua）；Liping County Family Planning Station, Liping County 557300,Guizhou Province, China（YANG Zheng-pin）；Zunyi County Health Care Service Center of Maternal and Child, Zunyi County 563100，Guizhou Province, China（XIAO Shi-wen）；Fenggang County Health Care Service Center of Maternal and Child, Fenggang County 564200，Guizhou Province, China（AN Wen-shi）；Yuqing County Health Care Service Center of Maternal and Child, Yuqing County564400，Guizhou Province, China（TIAN Ying-mei）
  • Received:1900-01-01 Revised:1900-01-01 Published:2012-03-15 Online:2012-03-15
  • Contact: ZHU Jiang

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摘要： 目的：考察喹喃克林女性非手术绝育（QS）术大规模临床使用的安全性、可靠性及可接受性。方法：2007年3月—2010年7月，在贵州省内募集6 000例自愿接受QS的妇女，即：将7粒（252 mg）喹喃克林小丸放入改良的T-铜宫内节孕器（IUD）放置器内，并于月经干净后3耀7d或分娩、人工流产后6周将小丸置入子宫。4周后完成第2次放药。术后 3，6，12，24个月进行随访。结果：回收随访表5 780份，妊娠表88份，随访时间最长1 248d。不良反应主要表现为阴道黄色分泌物、头晕、乏力、月经不调等，未见严重不良反应。绝育有效率为98.5%，上药状态和上药次数影响成功率。结论：QS费用低廉，操作简便、无创、无痛、不良反应小、更易为自愿绝育妇女和临床医生所接受。术前体检排除禁忌证、产后6周或月经后3耀7d上药、2次上药、术后平躺2h和术后避孕3个月有利于提高QS的成功率。QS的推广对于提高女性绝育的接受程度和降低计划生育手术费用都有着积极作用。

关键词: 绝育, 生殖道, 女（雌）性, 喹喃克林, 非手术绝育

Abstract: Objective：To assess the safety, effectiveness and acceptability of quinacrine sterilization(QS) when QS was cosmically used in clinic. Methods: This trial was completed from March 2007 to July2010. 6 000 female volunteers were recruited in Guizhou province. Seven pellets of QS (252 mg) were insertedinto uteri using the modified Cu-T intrauterine device (IUD) during days 3 to 7 after menstruation or >delivery/ postpartum 6 weeks. The second insertion of the same dose was performed 4 weeks of the first insertion.Questionnaires and physical examination were asked during the 3rd, 6th, 12th, and 24th months. Results: 5 780 cases were followed -up with the longest follow -up times,1248 days. The main side effects were yellow discharge from vagina, dizziness，tired, menstrual irregularity. There was not any serious side effect. The effective rate was 98.5% , which effected by the situation and time of QS insertion. Conclusions：QS wasachea, contraceptive with the characteristics of simple performance, non-wound and non-pain, low side effectand hign acceptability. Some factor can increase the QS effective rate, such as delivery / postpartum 6 weeks，3 to7 after menstruation，two times of insertion, lying down for 2 hours after QS procedure, contraceptive3 months after each insertion. QS contraceptive has positive role in improving acceptability of female sterilization and reducing cost of family planning.

Key words: Sterilization, reproductive, Female, Quinacrine, Non-surgical sterilization