国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2014, Vol. 33 ›› Issue (5): 392-395.

• 综述 • 上一篇    下一篇

辅助生殖技术受孕的妊娠结局

陈絮，李志凌   

  1. 515041 广东省汕头市，汕头大学医学院第一附属医院生殖医学科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2014-09-15 发布日期:2014-09-15
  • 通讯作者: 李志凌

Clinical Outcomes of Assisted Reproductive Technology

CHEN Xu，LI Zhi-ling   

  1. Department of Reproductive Medicine，the First Affiliated Hospital of Shantou University Medical College，Shantou 515041，Guangdong Province，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2014-09-15 Online:2014-09-15
  • Contact: LI Zhi-ling

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摘要： 随着实验仪器的更新、体外培养条件和环境的改进以及超排卵方案的完善，辅助生殖技术（assisted reproductive technology，ART）的妊娠率明显提高，同时ART的安全性问题也成为人们关注的焦点。不孕本身可能是ART妊娠不良结局的高危因素，ART助孕妊娠的妇女妊娠期高血压疾病、妊娠期糖尿病、前置胎盘、剖宫产率、早产率、多胎率以及低体质量儿出生率、先天性畸形率、新生儿远期疾病（生长发育异常、儿童恶性肿瘤、基因印迹异常）的发生率均高于自然妊娠。原因可能是与超量激素刺激、配子及胚胎的处理及冻融、体外培养和显微操作等有关。综述ART妊娠结局的研究进展。

关键词: 生殖技术, 辅助, 妊娠并发症, 妊娠结局

Abstract: With the improving equipment and laboratory technology，as well as the optimized protocols of controlled ovarian stimulation，the pregnancy rate of assisted reproductive techniques（ART） has significantly increased. Meanwhile，the security of ART is of a focus. Infertility itself may be the risk factor of adverse pregnancy outcomes of ART. The increased rates of gestational hypertension，gestational diabetes，placenta previa，cesarean section，premature birth，multiple pregnancy，low birth weight，congenital malformations，and some latent risks of neonatal long-term disease（abnormal growth and development，malignant tumors in children，gene imprinting abnormalities），in those ART pregnancies could be related to excess ovarian stimulation，manipulation and frozen-thawing of gamete and embryo，in vitro embryonic culture and micromanipulation. The pregnancy outcomes of ART and risk factors were reviewed.

Key words: Reproductive techniques, assisted, Pregnancy complications, Pregnancy outcome