国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2014, Vol. 33 ›› Issue (6): 481-484.

• 综述 • 上一篇    下一篇

精子头部空泡及其对体外受精影响的研究进展

李学余，张波，冯贵雪   

  1. 530003 南宁，广西壮族自治区妇幼保健院生殖中心
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2014-11-15 发布日期:2014-11-15
  • 通讯作者: 李学余

Effects of Sperm Head Vacuoles on Outcome of in Vitro Fertilization

LI Xue-yu，ZHANG Bo，FENG Gui-xue   

  1. Reproductive Medicine Center，Guangxi Maternal and Child Health Hospital，Nanning 530003，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2014-11-15 Online:2014-11-15
  • Contact: LI Xue-yu

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摘要： 将活动精子放大6 000倍以上进行活动精子细胞器官形态学检查（MSOME），可选择形态好的精子进行胞浆内单精子显微注射（ICSI）。MSOME对于精子头部空泡的检查十分专业，精子空泡到底是什么？会不会影响辅助生殖技术（ART）结局？回顾近年来有关空泡研究的相关文献，发现精子空泡有如下特征：①空泡十分多发；②空泡主要位于精子的头前中区域；③空泡可能存在异质性；④空泡的来源依然未明；⑤空泡与精液常规参数存在一定的相关性，有研究发现精子空泡与染色质凝聚异常、DNA碎片率及非整倍体率呈正相关，但结果依然存在争议；⑥空泡可能导致受精率、优胚率特别是临床妊娠率的降低。

关键词: 空泡, 精子, 生殖技术, 辅助, 精子注射, 细胞质内

Abstract: The motile sperm organelle morphology examination（MSOME），a morphological analysis of isolated motile spermatozoa in real-time at more than 6 000 times magnification，can help embryologist to select those sperms with normal morphology for intracytoplasmic sperm injection（ICSI）. MOSME is a very special method to identify sperm head vacuoles. What are sperm vacuoles? Whether may sperm vacuoles influence the outcome of ART? This article reviewed those characteristics of sperm vacuoles as follows：①Vacuoles were commonly found in sperm head; ②Vacuoles were distributed more frequently in the anteromedian region of sperm head; ③There were different types of vacuoles; ④The origin of sperm vacuoles was still unsure; ⑤There were correlation in a certain extent between sperm vacuoles and routine semen parameters. It was found，although unasserted，that sperm vacuoles were positively correlated with abnormal chromatin condensation，DNA fragmentation rate，and aneuploid rate; ⑥Spern vacuoles could lead to the lowed fertilization rate，the lowed rate of high-qualified embryo，and the lowed rate of clinical pregnancy specially.

Key words: Vacuole, sperm, Reproductive techniques, assisted, Sperm injections, intracytoplasmic