国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2015, Vol. 34 ›› Issue (5): 401-405.

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卵母细胞减数分裂中蛋白表达研究进展

易子云，全松   

  1. 510515 广州，南方医科大学南方医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2015-09-15 发布日期:2015-09-15
  • 通讯作者: 全松

Protein Expression during Oocyte Meiosis

YI Zi-yun，QUAN Song   

  1. Department of Obstetrics and Gynecology，Southern Medical University，Nanfang Hospital，Guangzhou 510515，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-09-15 Online:2015-09-15
  • Contact: QUAN Song

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摘要： 哺乳动物卵母细胞减数分裂成熟过程中存在3个重要时期：第一次减数分裂前期的双线期停滞，第一次减数分裂向第二次减数分裂的转变，第二次减数分裂中期阻滞。该过程复杂，丝裂原激活蛋白激酶、成熟促进因子、Septin蛋白、突触结合蛋白1、Rec8蛋白等多种已知或未知的蛋白参与其中，从细胞周期调节、纺锤体组装调节、染色体分离调节等3方面调控卵母细胞减数分裂成熟。综述这一过程中相关蛋白的表达规律、亚细胞定位及相互作用，着重描述了这些蛋白在哺乳动物卵母细胞减数分裂成熟中的可能作用及机制。

关键词: 卵母细胞, 减数分裂, 纺锤体, 染色体分离

Abstract: The meiosis and maturation of mammalian oocyte include three important periods： arresting at diplotene of the first meiotic prophase，entering into the second round of meiosis and arresting at metaphase of the second meiosis. This complicated process is controlled by a series of factors, known or unknown factors，such as mitogen-activated protein kinase，maturation promoting factor，Septin，Synaptotagmin 1，Rec8 and so on. They regulate the meiotic maturation of mammalian oocyte in the following three aspects: cell cycle，spindle assembly and chromosome segregation. This paper reviewed the expression pattern, subcellular locatization and interaction of those proteins or factors, and their potential functions and mechanisms during the meiotic maturation of mammalian oocyte.

Key words: Oocytes, Meiosis, Spindle, Chromosome segregation