国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2016, Vol. 35 ›› Issue (5): 395-399.

• 综述 • 上一篇    下一篇

脂肪因子对睾丸雄激素生成的调节作用

王晓烔，张晓柯，胡廉   

  1. 430030 武汉，华中科技大学同济医学院计划生育研究所
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2016-10-25 发布日期:2016-10-25
  • 通讯作者: 胡廉

Regulation of Adipokines on Testicular Androgen Production

WANG Xiao-tong，ZHANG Xiao-ke，HU Lian   

  1. Family Planning Research Institute，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430030，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2016-10-25 Online:2016-10-25
  • Contact: HU Lian

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摘要： 脂肪组织合成和分泌多种脂肪因子（adipokines），通过神经内分泌或直接作用于睾丸来调节生殖系统功能，在睾丸组织已发现多种脂肪因子的受体。瘦素（leptin）在下丘脑-垂体-性腺轴各个层面影响睾丸发育成熟、雄激素合成以及生精功能；脂联素（adiponectin）受体在睾丸组织表达，脂联素影响间质细胞的激素合成，还通过抗炎作用保护间质细胞；同样，抵抗素（resistin）和趋化素（chemerin）也参与调节睾酮合成。肥胖可导致脂肪因子分泌的改变，从而引起胰岛素敏感性下降、慢性炎症、血管病变等代谢相关的改变，也是导致雄激素下降、男性不育的原因之一。

关键词: 脂肪因子类, 受体, 脂肪因子, 睾丸, 瘦素, 不育, 男（雄）性, 肥胖症

Abstract: Many adipokines secreted by adipose tissue could regulate the testicular functions by neuroendocrine or direct action. Adipokine receptors have already been found in testis. Leptin affects the development of testis, androgen synthesis and spermatogenesis in all levels of hypothalamic pituitary gonadal axis. Adiponectin by the receptors expressed in Leydig cells can regulate androgen production, and protect these cells through its anti-inflammatory action. Resistin and chemerin are also involved in the regulation of testosterone synthesis. Obesity can change the secretion of adipokines, which induces the decreased insulin sensitivity, chronic inflammation, vascular disease and other metabolic diseases. All of them could be related with hypoandrogenism and male infertility.

Key words: Adipokines, Receptors, adipokine, Testis, Leptin, Infertility, male, Obesity