国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2016, Vol. 35 ›› Issue (6): 459-462.

• 论著 • 上一篇    下一篇

体外受精/胞浆内单精子注射子代围生期结局的回顾性分析

钱春凤，李红   

  1. 215002 南京医科大学附属苏州医院，苏州市立医院本部生殖与遗传中心
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2016-12-25 发布日期:2016-12-25
  • 通讯作者: 李红

The Perinatal Outcomes of Offsprings from IVF/ICSI: A Retrospective Study

QIAN Chun-feng , LI Hong   

  1. Center for Reproduction and Genetics, Nanjing Medical University Affiliated Suzhou Hospital, Suzhou Municipal Hospital, Suzhou 215002, Jiangsu Province, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2016-12-25 Online:2016-12-25
  • Contact: LI Hong

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摘要： 目的：回顾性分析体外受精（IVF）/胞浆内单精子注射（ICSI）子代的围生期结局。方法：分析2012年1月—2013年12月在南京医科大学附属苏州医院接受辅助生殖技术（ART）治疗鲜胚和冻胚移植840个活产周期的临床资料和围生期结局。结果：双胎妊娠出生体质量[（2 536.84±417.23）g vs. （3 314.67±466.56）g]和分娩孕周[（36.78±1.74）周 vs.（39.31±1.45）周]均低于单胎妊娠，差异有统计学意义（P＜0.05）；双胎妊娠早产发生率（45.66% vs. 3.70%）、低出生体质量儿发生率（41.32% vs. 2.41%）、剖宫产率（97.26% vs. 81.64%）高于单胎妊娠，差异有统计学意义（P＜0.05）。冻胚移植单胎妊娠出生体质量[（3 358.96±458.34）g vs. （3 249.11±474.28）g]和剖宫产率（85.97% vs. 74.58%）高于鲜胚移植，差异有统计学意义（P＜0.05）。结论：IVF/ICSI技术获得的双胎妊娠较单胎妊娠不良围生期结局更多；在单胎妊娠中冻胚移植出生体质量和剖宫产率高于鲜胚移植。

关键词: 生殖技术, 辅助, 双生, 妊娠结局, 早产, 婴儿, 出生时低体重, 性别比率

Abstract: Objective: To investigate the perinatal outcomes of offsprings from IVF/ICSI. Methods: The clinical data and perinatal outcomes of 840 cycles of fresh embryo transfer or frozen-thawed embryo transfer（FET） were retrospectively analyzed in our hospital from January 2012 to December 2013. Results: The birth weight [（2 536.84±417.23）g vs.（3 314.67±466.56）g] and the gestational age[（３６．７８±１．７４）week vs.（３９．３１±１．４５）week] of the twins were significantly lower than singletons（Ｐ＜０．０５）. The rates of premature birth（45.66% vs. 3.70%）, low birth weight（41.32% vs. 2.41%） and cesarean section（97.26% vs. 81.64%） in the twins were significantly higher than the singletons（Ｐ＜０．０５）. The birth weight[（3 358.96±458.34）g vs. （3 249.11±474.28）g] and the cesarean section （85.97% vs. 74.58%）in the singletons of FET group were significantly higher than those in the fresh embryo transfer group （P＜0.05）. Conclusions: The twins of ART have more adverse perinatal outcomes than the singletons. The singletons of FET have better outcomes than the singletons of fresh embryo transfer.

Key words: Reproductive techniques, assisted, Twins, Pregnancy outcome, Premature birth, Infant, low birth weight, Sex ratio