关键词: 多囊卵巢综合征, 胰岛素抗药性, 治疗, 慢性炎症, 高雄激素血症

Abstract: Polycystic ovary syndromes (PCOS), a common endocrine disorder in women of puberty and childbearing age, is characterized by ovulation disorder, insulin resistance (IR) and hyperandrogenemia (HA). It is one of the main causes of female infertility. Chronic inflammation is an important way of defense for the body. However, it is also one of the causes of metabolic diseases. Patients with PCOS have chronic and low-grade inflammation, because the levels of some inflammatory factors were abnormally increased in those patients. More and more evidences have suggested the close relationship between chronic inflammation and the pathogenesis of PCOS, although there is still some controversy. Many inflammatory factors were secreted during the pathophysiological duration of PCOS, which causes the chronic low-grade inflammation. New evidences suggested that chronic inflammation may be actually involved in obese, IR and HA in the early stage of PCOS. Some anti-inflammatory drugs have been used to improve the inflammatory microenvironment of PCOS in the clinical practice, with a definite effect. In this paper, the relationship between chronic inflammation and the pathogenesis of PCOS, as well as the research progress was reviewed.

Key words: Polycystic ovary syndrome, Insulin resistance, Therapy, Chronic inflammation, Hyperandrogenemia