国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2019, Vol. 38 ›› Issue (4): 323-327.

• 综述 • 上一篇    下一篇

CircRNA在女性生殖系统疾病中的研究进展

赵鸿娟，蒋元欣，王煜   

  1. 250000 济南，山东省立第三医院妇产科（赵鸿娟）；内蒙古医科大学（蒋元欣）；内蒙古医科大学附属医院（王煜）
  • 收稿日期:2019-04-08 修回日期:2019-05-06 出版日期:2019-07-15 发布日期:2019-07-15
  • 通讯作者: 王煜，E-mail：wuai1544@163.com E-mail:425echo@163.com
  • 基金资助:
    国家自然科学基金（81560260）；内蒙古自治区自然科学基金（2017MS0366）；内蒙古自治区高等学校青年科技英才计划（NJYT-18-B12）；中华医学会临床医学科研专项基金（2017）

Progress of CircRNA in Female Reproductive System and Diseases

ZHAO Hong-juan，JIANG Yuan-xin，WANG Yu   

  1. Department of Obstetrics and Gynecology，Shandong Provincial Third Hospital，Jinan 250000，China（ZHAO Hong-juan）；Inner Mongolia Medical University，Hohhot 010059，China（JIANG Yuan-xin）；Inner Mongolia Medical University Affiliated Hospital，Hohhot 010050，China（WANG Yu）
  • Received:2019-04-08 Revised:2019-05-06 Published:2019-07-15 Online:2019-07-15
  • Contact: WANG Yu，E-mail：wuai1544@163.com E-mail:425echo@163.com

PDF (PC)

9038

摘要： 环状RNA（circRNA）作为新发现的RNA家族中的一员，随着RNA测序水平的发展已经成为最新的研究热点。CircRNA是一种具有特殊闭合环状结构的RNA，由于形态的特殊性，决定了其与线性RNA的特性不同。CircRNA具有稳定性、物种保守性及组织细胞特异性，在circRNA-微小RNA（miRNA）-mRNA轴中充当miRNA海绵作用，可调控基因转录及蛋白质翻译。研究发现，女性生殖系统疾病的发生、发展可能与circRNA的异常密切相关。通过研究各种circRNA的特性及其发挥作用的机制，可以发现circRNA作为生物标志物及疾病预后指标具有一定的发展前景。现对circRNA与女性生殖系统疾病之间的潜在作用机制进行综述。

关键词: 环状RNA, 微RNAs, 生殖器肿瘤, 女（雌）性, 生殖技术, 辅助, 综述

Abstract: With the development of RNA sequencing, cyclic RNA (circRNA) has been a research hot which is a member of the newly discovered RNA family. CircRNA is a kind of RNA with a special closed ring structure. Because of the special morphology, circRNA has some characteristics which are different from those of linear RNA. CircRNA is stable and conservative across species, and has tissue and cell specificity. CircRNA can act as the so-called microRNA (miRNA) sponge in the circRNA-miRNA-mRNA regulatory axis, regulating gene transcription and protein translation. Studies have found that the pathogenesis of female reproductive diseases may be closely related to the abnormality of circRNA. By studying the characteristics and mechanisms of various circRNA, circRNA may be used as a biomarker and prognostic indicator of disease in future. The article reviews the potential mechanisms of circRNA in female reproductive system and diseases.

Key words: Circular RNA, MicroRNAs, Genital neoplasms, female, Reproductive techniques, assisted, Review

中图分类号: