国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2019, Vol. 38 ›› Issue (3): 236-239.

• 综述 • 上一篇    下一篇

上皮-间质转化与女性生殖系统发育、功能及疾病

温思茜，宋亚丽，刘婧，全松   

  1. 510515 广州，南方医科大学南方医院妇产科生殖医学中心
  • 收稿日期:2019-01-04 修回日期:2019-01-31 出版日期:2019-05-15 发布日期:2019-05-16
  • 通讯作者: 全松，E-mail：quansong@smu.edu.cn E-mail:quansong@smu.edu.cn

Epithelial-Mesenchymal Transition and the Development, Function and Diseases of Female Reproductive System

WEN Si-xi, SONG Ya-li, LIU Jing, QUAN Song   

  1. Reproductive Medical Center, Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
  • Received:2019-01-04 Revised:2019-01-31 Published:2019-05-15 Online:2019-05-16
  • Contact: QUAN Song, E-maｉｌ： quansong@smu.edu.cn E-mail:quansong@smu.edu.cn

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摘要： 上皮-间质转化（epithelial-mesenchymal transition，EMT）是指上皮细胞在形态学上发生向成纤维细胞或间质细胞表型转化的过程，在胚胎发育、组织再生、肿瘤转移和器官纤维化疾病中发挥重要作用。随着EMT在生殖领域不断被发现，EMT作为女性生殖系统的重要调控机制越来越受到关注。本文综述了EMT在女性生殖系统形成、发育及正常功能中的重要性，并讨论EMT在病理状态如子宫内膜异位症、宫腔粘连和生殖系统恶性肿瘤等疾病发生中的作用，以期为女性生殖系统的研究及疾病治疗提供新思路。

关键词: 上皮-间质转化, 女（雌）性泌尿生殖系统疾病, 不育, 女（雌）性, 子宫内膜异位症

Abstract: Epithelial-mesenchymal transition (EMT) is the process by which epithelial cells undergo morphological transformation into fibroblasts or mesenchymal cells. EMT plays an important role in embryonic development, tissue regeneration, tumor metastasis, and organ fibrosis. With the continuous discovery of EMT in the field of reproduction, EMT has received attention as an important regulatory mechanism for the female reproductive system. In this review, we discusse the importance of EMT in the formation, development and normal function of female reproductive system, and expound the role of EMT in pathological conditions such as endometriosis, intrauterine adhesions and reproductive system malignancies in order to provide new ideas for the research and treatment of female reproductive system.

Key words: Epithelial-mesenchymal transition, Female urogenital diseases, Infertility, female, Endometriosis

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