富血小板血浆治疗薄型子宫内膜的作用机制

doi:10.12280/gjszjk.20210162

摘要/Abstract

摘要：

薄型子宫内膜可导致临床妊娠率和活产率降低,目前尚无改善薄型子宫内膜患者子宫内膜厚度的最佳方案。富血小板血浆（platelet-rich plasma,PRP）灌注治疗作为改善子宫内膜厚度的一种新型的治疗方法,在治疗薄型子宫内膜的确切作用较为复杂。PRP所含有的血小板浓度高于全血中通常所含的血小板浓度,而使用高浓度血小板的基本原理和治疗潜力是基于它们可以提供超生理剂量的必需生长因子,以提供再生刺激,促进具有低愈合潜力的组织修复。现基于目前国内外PRP治疗薄型子宫内膜的研究进展,探讨PRP内生长因子促细胞增殖、迁移及通过核因子κB（nuclear factor-κB,NF-κB）信号通路调节子宫内膜细胞增殖和凋亡的作用,为进一步研究PRP治疗的分子基础及确切的作用机制提供参考。

关键词: 薄型子宫内膜, 富血小板血浆, 生长因子, 胞间信号肽类和蛋白质类, NF-κB

Abstract:

Thin endometrium can lead to the decreased rates of clinical pregnancy and live birth. At present, there is no optimal plan to improve endometrial thickness in patients with thin endometrium. As an auxiliary method for emerging endometrial preparation, platelet-rich plasma (PRP) perfusion therapy may have a complex mechanism in the treatment of thin endometrium. The platelet concentration in PRP is higher than that in whole blood. The basic principle and therapeutic potential of high concentration platelets are based on their ability to provide superphysiological quantities of essential growth factors for regenerative stimulation and to promote tissue repair with low healing potential. Based on the research progress of PRP, this paper focuses on the growth factors in PRP to promote cell proliferation, migration, and to regulate the proliferation and apoptosis of endometrial cells through NF-κB signaling pathway. The discussion will provide a reference for further study of the molecular basis and exact mechanism of PRP therapy.

Key words: Thin endometrium, Platelet-rich plasma, Growth factors, Intercellular signaling peptides and proteins, NF-kappa B

郑秀丹, 尹兰兰, 王艳波, 马天仲. 富血小板血浆治疗薄型子宫内膜的作用机制[J]. 国际生殖健康/计划生育, 2021, 40(6): 490-494.

ZHENG Xiu-dan, YIN Lan-lan, WANG Yan-bo, MA Tian-zhong. The Mechanism of Platelet-Rich Plasma Therapy in Thin Endometrium[J]. Journal of International Reproductive Health/Family Planning, 2021, 40(6): 490-494.

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