线粒体功能异常与卵巢储备功能减退

doi:10.12280/gjszjk.20240358

摘要/Abstract

摘要：

卵巢储备功能减退（diminished ovarian reserve，DOR）是女性生殖健康领域的重要问题，其特征为卵巢内可用卵子数量的减少或质量的下降。线粒体为细胞提供能量，细胞各种活动皆依赖于线粒体功能的正常运转，对于女性生殖系统而言，胚胎发育潜能和卵母细胞质量下降以及卵巢衰老均与线粒体功能异常密切相关。线粒体功能异常通过线粒体数量下降、线粒体DNA拷贝数异常、线粒体DNA突变/缺失、线粒体自噬等方式影响卵巢储备功能。综述线粒体功能异常在DOR及相关疾病发生发展中潜在机制的研究进展。

关键词: 卵巢储备功能, 线粒体, 氧化应激, 卵母细胞, 线粒体自噬

Abstract:

Diminished ovarian reserve (DOR) is a significant concern in the field of female reproductive health, characterized by a decrease in the quantity or quality of available eggs within the ovaries. Mitochondria serve as the powerhouses of the cell, and various cellular activities depend on the normal functioning of mitochondria. For the female reproductive system, mitochondrial dysfunction is closely associated with ovarian aging, poor oocyte quality, and diminished embryonic developmental potential. Mitochondrial dysfunction can impact the ovarian reserve through multiple mechanisms such as the decreased mitochondrial quantity, abnormal mitochondrial DNA copy number, mitochondrial DNA mutations/deletions, and mitochondrial autophagy. In this article, we discuss the effect of mitochondrial dysfunction in the pathophysiological mechanisms of DOR and DOR-related diseases.

Key words: Ovarian reserve, Mitochondria, Oxidative stress, Oocytes, Mitophagy

徐强, 张曼丽, 腊晓琳. 线粒体功能异常与卵巢储备功能减退[J]. 国际生殖健康/计划生育杂志, 2025, 44(1): 54-58.

XU Qiang, ZHANG Man-li, LA Xiao-lin. Mitochondrial Abnormalities in Diminished Ovarian Reserve[J]. Journal of International Reproductive Health/Family Planning, 2025, 44(1): 54-58.

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