国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2013, Vol. 32 ›› Issue (2): 111-113.

• 综述 • 上一篇    下一篇

口服避孕药保护卵巢功能的研究进展

金爱红,顾江红   

  1. 310053 杭州，浙江中医药大学（金爱红）；浙江中医药大学附属广兴中医院（顾江红）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2013-03-15 发布日期:2013-03-15

Research Progress on Oral Contraceptives Protecting Ovarian Function

JIN Ai-hong，GU Jiang-hong   

  1. Zhejiang Chinese Medical University，Hangzhou 310053，China（JIN Ai-hong）；Department of Obstetrics and Gynecology，Guangxing Hospital Affiliated Zhejiang Chinese Medical University，Hangzhou 310007，China（GU Jiang-hong）
  • Received:1900-01-01 Revised:1900-01-01 Published:2013-03-15 Online:2013-03-15

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摘要： 随着化疗药物在肿瘤及自身免疫性疾病的广泛应用，由其导致的卵巢早衰是临床亟待解决的问题。许多研究认为口服避孕药负反馈降低促性腺激素的合成和分泌，使卵巢处于静止状态，免受细胞毒性药物损伤，同时可上调Bcl-2表达及下调Bax表达，抑制卵泡颗粒细胞及卵母细胞凋亡，通过减少氧自由基产生，保护和改善细胞膜的完整性和流动性，调节卵巢组织细胞功能。探讨口服避孕药保护卵巢功能的作用机制，可对进一步研究及临床应用提供依据。

关键词: 卵巢功能早衰, 化学疗法, 辅助, 避孕药, 口服

Abstract: Premature ovarian failure （POF） is an important problem when chemotherapy drugs were used in cancer and autoimmune diseases. Oral contraceptions （OCs） can reduce gonadotropins synthesis and secretion by the negative feedback which make ovary dormant status against the damage of cytotoxic drugs. Meanwhile, OCs can restrain apoptosis of follicle granular cell and oocyte by up-regulating Bcl-2 expression and down-regulating Bax expression. The integrity and liquidity of cell membrane can be protected by reducing the oxygen free radicals production. This article reviewed the mechanism of oral contraceptives protecting ovarian function.

Key words: Ovarian failure, premature, Chemotherapy, adjuvant, Contraceptives, oral