国际生殖健康/计划生育 ›› 2015, Vol. 34 ›› Issue (3): 255-259.

• 综述 • 上一篇    下一篇

子宫内膜异位症的治疗新进展

何晔,魏兆莲   

  1. 230022 合肥,安徽医科大学第一附属医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2015-05-15 发布日期:2015-05-15
  • 通讯作者: 魏兆莲

Research Progress in Endometriosis Treatment

HE Ye,WEI Zhao-lian   

  1. Department of Obstetrics and Gynecology,The First Affiliated Hospital of Anhui Medical University,Hefei 230022,China
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-05-15 Online:2015-05-15
  • Contact: WEI Zhao-lian

摘要: 子宫内膜异位症(endometriosis,EMs)即子宫内膜基质和腺体组织出现在子宫内膜以外的身体其他部位,是好发于育龄期妇女生殖系统的具有侵袭性及雌激素依赖性的良性疾病,其发病机制迄今不明,可引起痛经、慢性盆腔痛、生育能力低下及月经失调等症状,严重影响了女性的生殖健康和生活质量。传统药物治疗手段效果欠佳、不良反应明显,而手术治疗复发率较高。随着近年EMs相关基础及病因学的研究深入,学者们提出EMs可能是由多种因素共同作用导致的疾病,因此提出了抗细胞增殖、抗血管生成、抗炎、选择性雌激素受体拮抗剂以及干细胞治疗等新的治疗理念,作用于疾病发生和发展的各个方面。同时随着辅助生殖技术的发展,体外受精-胚胎移植(IVF-ET)成为目前EMs合并不孕症患者的最有效的治疗方式。

关键词: 子宫内膜异位症, 治疗, 药物疗法, 干细胞, 生殖技术, 辅助

Abstract: Endometriosis, a chronic and estrogen-dependent benign disease which is defined as the endometrium tissue with glands and stroma located abnormally in any other tissue out of uterus, affects women in the reproductive age. Its clinical features include dysmenorrhea,chronic pelvic pain, infertility and menstrual disorder, which have finally negative effects on the quality of life. However, the exact pathogenic mechanisms have not been entirely clarified. Conventional medical therapies often have only modest success and numerous side effects;the recurrence rate of surgical therapy is relatively high. With the research progress in the last decades,it is pointed out that endometriosis is a complicated multifactorial syndrome. New concepts of endometriosis treatment include antiproliferative and antiangiogenic agents,anti-inflammatory drugs,selective estrogen receptor agonists, and the potential application of stem cells. As for those endometriosis-associated infertilities, the in vitro fertilization-embryo transfer is currently the most effective treatment.

Key words: Endometriosis, Therapy, Drug therapy, Stem cells, Reproductive techniques, assisted