国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2015, Vol. 34 ›› Issue (3): 251-254.

• 综述 • 上一篇    下一篇

改善子宫内膜发育不良的药物治疗

孙旸，梁婧，兰晓霞，侯海燕，陈亚琼   

  1. 300162 天津，中国人民武装警察部队后勤学院附属医院妇产科（孙旸，侯海燕，陈亚琼）；天津中医药大学（孙旸，梁婧）；中国人民武装警察部队学院医学统计与流行病学教研室（兰晓霞）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2015-05-15 发布日期:2015-05-15
  • 通讯作者: 陈亚琼

Recent Progress of Medicine for Endometrial Hypoplasia

SUN Yang，LIANG Jing，LAN Xiao-xia，HOU Hai-yan，CHEN Ya-qiong   

  1. Department of Obstetrics and Gynecology，Affiliated Hospital，Logistics University of Chinese People′s Armed Police Forces，Tianjin 300162，China（SUN Yang，HOU Hai-yan，CHEN Ya-qiong）；Tianjin University of Traditional Chinese Medicine，Tianjin 300193，China（SUN Yang，LIANG Jing）；Department of Epidemiology and Principle of Statistics，Logistics University of Chinese People′s Armed Police Forces，Tianjin 300309，China（LAN Xiao-xia）
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-05-15 Online:2015-05-15
  • Contact: CHEN Ya-qiong

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摘要： 子宫内膜发育不良是辅助生殖技术中的难点问题，其病因为子宫内膜容受性降低。多数患者因既往流产史、清宫史或患有其他疾病（如结核病史等）所致。目前改善子宫内膜容受性的治疗方法种类多，且近年许多药物应用于子宫内膜容受性的治疗中，如干细胞、粒细胞集落刺激因子、促性腺激素释放激素激动剂、磷酸二脂酶5抑制剂（如万艾可等），芬吗通、小剂量阿司匹林、生长激素和中药等。上述药物治疗在部分患者中取得了满意疗效，即改善子宫内膜容受性和提高临床妊娠率。现就中西药物的治疗方法及治疗效果进行分析总结，以期为今后研究与应用提供参考。

关键词: 子宫内膜, 药物疗法, 生殖技术, 辅助, 子宫内膜发育不良

Abstract: It is difficult to treat the endometrial dysplasia in assisted reproductive technology due to the reduced endometrial receptivity. Most causes of the endometrial dysplasia are previous abortion, artificial abortion or other diseases (such as tuberculosis history). There are many types of treatment to improve endometrial receptivity, and more and more treatment methods were also used, such as stem cells, granulocyte colony-stimulating factor, gonadotropin-releasing hormone agonist, 5-phosphate diesterase inhibitors (viagra, etc), femoston, a small dose of aspirin, growth hormone and traditional Chinese medicine. These treatment methods achieved good curative effect including the improved endometrial receptivity and the increased clinical pregnancy rate in some patients. This review summarized the treatment of endometrial dysplasia with Chinese and western medicine, as well as recent progress.

Key words: Endometrium, Drug therapy, Reproductive techniques, assisted, Endometrial hyperplasia