Abstract: Polycystic ovary syndrome（PCOS）is a clinical syndrome with metabolic abnormity and
endocrine disorder. At present the abnormal follicular growth and development, which cause the clinical
metabolic and endocrine change of PCOS, was considered as the pathophysiologic basis. Anti-Mullerian
hormone（AMH）, also known as Mullerian inhibiting substance（MIS）and belongs to transforming growth
factors-β（TGF-β）superfamily, is expressed in the growth of follicles of ovarian granulosa cells and regulates
the growth and development of follicles. AMH plays an important role in the initial recruitment and periodic
recruitment of normal follicles. A number of studies have shown that the abnormal inherent growth and
development of follicles in ovarian granulosa cells might be related to abnormal secretion of AMH, and in
PCOS patients the abnormal increase of AMH might cause abnormal growth of follicles and ovulation disorder.
The study on AMH may provide a new theoretical foundation for the pathogenesis of PCOS, as well as offer a
new pathway for clinical diagnosis and treatment of PCOS.

Key words: Polycystic ovary syndrome, Anti－Mullerian hormone, Granulosa cell, Follicles