Abstract: Androgens，via the interaction with their receptors，play important roles in the control of cellular growth and differentiation. Androgen receptors（AR） is a member of the superfamily of nuclear receptors, the ligand-dependent transactivators. AR has two subtypes：AR-α and AR-β. AR expressed in numerous target tissues, normal and pathological tissues，such as reproductive malignancies. It has been suggested that AR played important roles in the development of reproductive malignancies by multiple pathways, and that AR may be a new treatment target of those cancers. We hereby reviewed the recent finding on the effects of androgen and AR on the carcinogenesis and development, as well as potential application of AR as a target in treatment of reproductive malignancies.

Key words: Androgens, Receptors, androgen, Urogenital neoplasms