Abstract: Objective: To investigate the glucose and lipid metabolism indexes in patients with normal glucose tolerance and polycystic ovary syndrome （ＰＣＯＳ）. Methods：PCOS was diagnosed according to the Rotterdam Criterion. One hundred and forty-four patients with PCOS undertaken the oral glucose tolerance test （OGTT） and the insulin release test （ＩＲＴ）． One hundred healthy women with normal menstrual cycle served as the control group. Results：Compared with the control group, PCOS patients with normal glucose tolerance had a higher BMI, higher serum glucose and insulin levels at 0, 30, 60 and 180 min in OGTT and IRT, higher levels of HOMA-IR and HOMA-β, and the increased area under curves （ＡＵＣｓ） of glucose and insulin （Ｐ＜０．０５）． Additionally, the subgroup analysis was employed based on BMI. In PCOS patients with normal glucose tolerance, the obese subgroup （BMI≥25 kg/m2） had higher serum glucose and insulin levels at 0, 60, 120 and 180 min in OGTT and IRT, higher levels of HOMA-IR and HOMA-β, and the increased level of TG when compared with the non-obese subgroup （Ｐ＜０．０５）, which indicated that the ability of glucose and lipid metabolism in those obese PCOS patients was still impaired though they were with normal glucose tolerance after OGTT. Conclusions：OGTT and IRT should be routinely suggested for those PCOS patients with normal glucose tolerance so as to find the potential insulin resistence and to intervent early. For those obese PCOS patients with normal glucose tolerance, it should be advised to check actively the levels of insulin and serum lipid and to have termly the follow-up visit.

Key words: Polycystic ovary syndrome, Glucose tolerance test, Blood glucose, Insulin, Insulin resistance