Abstract:

Endometrial polyps (EPs) is a kind of pathological changes of endometrium, which is composed of endometrial glands and endometrial stroma containing blood vessels. Although EPs is a common gynecologic disease, the pathogenesis is still unclear. With the wide use of hysteroscopy, the diagnosis and treatment level of EPs has been significantly improved. Many studies using molecular biology and sequencing technology have shown that microbiota exists in the upper and lower genital tract of healthy women, and that the composition of microbiota is different. Recent studies have found that the change of genital tract microbiota is closely related to female reproductive health. The correlation between the genital tract microbiota and the pathogenesis of EPs is one of the research hotspots. The genital tract microbiota may participate in the development of EPs by affecting local immune regulation, causing inflammatory response, changing hormone levels, increasing the number of pathogenic microbiota and affecting cell proliferation/apoptosis. Here we review the correlation between the genital tract microbiota and EPs, which can provide a reference to explore the pathogenesis of EPs.

Key words: Endometrium, Polyps, Reproductive tract infections, Microbiota, Inflammation