Angiopoietin-Like Proteins in Insulin Resistance,and Glucose Metabolism and Its Roles in Polycystic Ovary Syndrome

doi:10.12280/gjszjk.20210516

Abstract

Abstract:

Polycystic ovary syndrome (PCOS) is one of the most common endocrine and metabolic diseases in women of reproductive age. The risk of cardiovascular disease and type 2 diabetes is increased in PCOS patients.More and more studies support that insulin resistance (IR) is one of the important pathological mechanisms of PCOS. The angiopoietin-like proteins (ANGPTLs) family is a group of secreted glycoproteins structurally similar to angiopoietins, and so far, eight members have been found, namely ANGPTL1-ANGPTL8. The expression level of ANGPTLs in the blood of PCOS patients is increased, which is closely related to the degree of IR. ANGPTLs are involved in the regulation of IR and glucose metabolism by promoting adipose tissue inflammation, regulating insulin secretion and PI3K/Akt signaling pathway, which may be related to the pathogenesis of PCOS. We review the mechanism of ANGPTLs involved in IR and glucose metabolism and its role in PCOS, in order to further explore the mechanism of ANGPTLs involved in the pathogenesis of PCOS and provide new ideas for the prediction and treatment of PCOS.

Key words: Polycystic ovary syndrome, Insulin resistance, Angiopoietin-like proteins, Glucose metabolism, Metabolic diseases

WANG Jing-nan, ZHANG Xiao-hong, HAO Xiao-ying. Angiopoietin-Like Proteins in Insulin Resistance,and Glucose Metabolism and Its Roles in Polycystic Ovary Syndrome[J]. Journal of International Reproductive Health/Family Planning, 2022, 41(2): 160-165.

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