Roles of Growth Differentiation Factor 15 in Gestational Diseases

doi:10.12280/gjszjk.20220004

Abstract

Abstract:

Gestational diseases are a series of diseases related to the abnormal physiological function of maternal and fetus during pregnancy, which seriously impair the health of maternity and infant. Recent studies have shown that the highly-specifical expression of growth differentiation factor 15(GDF15) in placental tissue is crucial to maintain gestation and to promote normal fetal development, and the expression of GDF15 is abnormal in the placental tissue of various gestational diseases, including hyperemesis gravidarum, abortion, pregnancy anemia, gestational diabetes and gestational hypertension, etc. GDF15 as a multifunctional cytokine could participate in the regulation of energy metabolism during pregnancy by regulating insulin resistance and glucose tolerance. GDF15 could also play an important role in the regulation of immune balance during pregnancy by regulating the functions of macrophages, dendritic cells and other immune cells. We review the roles of GDF15 in the pathogenesis and pathophysiology of gestational diseases.

Key words: Growth differentiation factor 15, Abortion, Anemia, Diabetes, gestational, Hypertension, pregnancy-induced

SHI Zi-yun, LIANG Jing, ZHANG Ying. Roles of Growth Differentiation Factor 15 in Gestational Diseases[J]. Journal of International Reproductive Health/Family Planning, 2022, 41(4): 337-341.

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