Journal of International Reproductive Health/Family Planning

Journal of International Reproductive Health/Family Planning ›› 2017, Vol. 36 ›› Issue (6): 498-502.

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Effects of MicroRNAs on Early Embryonic Development and Implantation

XU Dan, WANG Yu-xia, YANG Hai-ting, PAN Cui-jiao   

  1. Department of Reproductive Medicine, The First Affiliated Hospital, Jinan University, Guangzhou 510630, China
  • Received:2017-09-15 Revised:2017-10-18 Published:2017-11-15 Online:2017-11-15
  • Contact: WANG Yu-xia，E-mail：sunneywang@126.com E-mail:sunneywang@126.com

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Abstract: MicroRNAs (miRNAs) play a regulatory role in early embryonic development and implantation. Abnormal expression of miRNAs may result inabnormal embryonic development and implantation failure by inducing the excessive apoptosis of trophoblasts, abnormal placental angiogenesis, inhibition of endometrial decidualization and maternal-fetal interface immune response. Moreover, the polymorphism of miRNAs leads to the embryo loss by inhibiting the proliferation of trophoblast cells and promoting apoptosis. In this article, the influence of miRNAs on early embryonic development and implantation was reviewed.

Key words: MicroRNAs, Embryonic development, Embryo implantation, Trophoblast cell