Effects of Branched-Chain Amino Acids on Metabolism and Reproduction in Polycystic Ovary Syndrome

doi:10.12280/gjszjk.20220391

Abstract

Abstract:

Polycystic ovary syndrome(PCOS) is a common reproductive endocrine disease in women of childbearing age. Patients are often accompanied by clinical manifestations such as insulin resistance, obesity, infertility and poor pregnancy outcome, which seriously affect women′s physical and mental health. Recent studies have shown that some patients with PCOS have the metabolic abnormality of branched-chain amino acids (BCAA), and that BCAA may be used as a marker to predict the risk of PCOS related complications. As an essential amino acid of human body, BCAA plays an important role in maintaining the homeostasis of the body by participating in the regulation of insulin secretion, and fat generation and differentiation. The change of BCAA level will affect the reproductive function of women. In addition, the excessive level of serum BCAA in PCOS patients is related to the disorders of glucose and lipid metabolism, the insulin resistance and obesity, and the adverse effect on ovulation and pregnancy in those patients of childbearing age. In this paper, the roles of BCAA in the metabolism of glucose and lipid and reproduction, as well as research progress, were reviewed, so as to provide new ideas for the diagnosis and treatment of metabolic and reproductive diseases in PCOS patients.

Key words: Amino acids, branched-chain, Polycystic ovary syndrome, Insulin resistance, Obesity, Reproduction

FENG Xiao-ling, CHEN Yao, WANG Ying. Effects of Branched-Chain Amino Acids on Metabolism and Reproduction in Polycystic Ovary Syndrome[J]. Journal of International Reproductive Health/Family Planning, 2023, 42(1): 72-76.

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