Advances in CircRNAs Research in Reproductive System

doi:10.12280/gjszjk.20240127

Abstract

Abstract:

Circular RNAs (circRNAs) are a class of endogenous non-coding RNA (ncRNA) without 5′N⁷-methylguanosine caps and 3′polyadenylated tails, forming a close loop structure with covalent bonds. Due to the specificity of circRNAs structure, it is highly resistant to ribonucleic acid exonuclease R (RNaseR) and is therefore quite abundant in the cytoplasm. The continuous development of high-throughput sequencing and bioinformatics methods has revealed that circRNAs are highly conserved, stable, disease-specific, and tissue-specific, giving them potential as biomarkers in early clinical diagnosis. Studies have demonstrated that circRNAs interact with oogenesis, ovarian aging, and ovary-related diseases in the female reproductive system, and with spermatogenesis and testicular development in the male reproductive system. CircRNAs are expected to be new diagnostic and therapeutic targets for a variety of reproductive disease. In the paper, we will focus on the biological functions and regulatory roles of circRNAs in reproductive system.

Key words: RNA, circular, Genital diseases, male, Genital diseases, female, Embryonic development, Spermatogenesis

JIAO Meng-wen, ZHANG Yue-wen, WANG Ling, MO Shao-kang. Advances in CircRNAs Research in Reproductive System[J]. Journal of International Reproductive Health/Family Planning, 2024, 43(4): 322-327.

Figures/Tables 1

References 38

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