Abstract:

Pre-eclampsia is a pregnancy-specific disease,the pathogenic mechanisms of pre-eclampsia remain largely undefined. Pregnancy activates many of the different components of circulating and local RAS. Research on different regulation of RAS between normal pregnant and pre-eclampsia may provide insight into the pathogenesis of pre-eclampsia. This article reviews changes of RAS in circulation and uteroplacental unit in Pre-eclampsia. Unlike in normal pregnancies,many components in circulating RAS including AngⅠ,AngⅡ,Ang-(1-7) and plasma renin activity is downregulated in women with pre-eclampsia,serum ACE is increased,.and serum AT1 antibodies (AT1-AA) are also higher. In pre-eclamptic placenta, total renin and active renin concentration are significantly increased and AT1 receptor mRNA, protein are upregulated.Ang II peptide levels and renin activity and ACE mRNA in the rterine placental bed are significantly higher in the uterine placental bed.

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