Abstract: Objective：To analyze retrospectively the infertile factors of patients with polycystic ovary syndrome （PCOS） and the pathological mechanism, and to discuss its comprehensive therapy. Methods：Clinical analysis of the pathological mechanism of infertility induced by PCOS in 50 PCOS patients was did from infertility clinic in our hospital from Jan-09 to Apr-11，including the comprehensive treatment. Results：In 50 cases, there were 39 cases with mature follicles（78.0%），30 cases of pregnant（60.0%），5 cases of threatened abortion（16.7%），5 cases of missed abortion（16.7%），2 cases of ovarian hyperstimulation syndrome（OHSS）（6.7%），1 case of twin pregnancy（3.3%），2 cases of ectopic pregnancy （6.7%），23 cases were labored successfully. Conclusions：PCOS is a endocrine disorder of multiple etiological factors and clinical manifestations including hyperandrogenism，insulin resistance and hyperproinsulinemia. So the treatment for PCOS infertility should be comprehensive.

Key words: Polycystic ovary syndrome