Abstract: Polycystic ovary syndrome（ＰＣＯＳ）, a common female reproductive dysfunction, is a endocrine disorder related with glycometabolism. Visfatin is a new member of the adipocytokine family. The level of serum visfatin was found to be higher in PCOS patients, expecially in those PCOS patients with obesity and insulin resistance (IR). The levels of visfatin were also increased in the serum samples and endometrial tissues of endometrial cancer. The risk of endometrial cancer was increased in those patients with obesity and IR, while the endometrial cancer was thought as one of the long-term complications of PCOS. Visfatin was closely related to IR, obesity and the long-term complications of endometrial lesions in PCOS. Visfatin may be a new potential target for the PCOS treatment and further study.

Key words: Nicotinamide phosphoribosyltransferase, Insulin resistance, Polycystic ovary syndrome, Review