Abstract: The incidence of early threatened abortion is increasing, which is one of the major obstetric diseases of particular concern. It is important that obstetrician should focus on the monitoring and treatment of early threatened abortion. After reviewing literatures, we found that the important roles of carbo hydrate antigen 125 (CA125) in early threatened abortion have been raised more and more concern. Serum CA125 may be one of the predictors and diagnostic markers of early threatened abortion. Many drugs such as progesterone, didroxyprogesterone and human chorionic gonadotropin can effectively improve the pregnancy success rate and reduce the level of serum CA125. Based on different mechanism, these drugs can be tried in different patients. However, there is no unified statement on the relationship between early threatened abortion and serum CA125, and the related basic values and thresholds of CA125 in early threatened abortion are not clear. Relevant details need further study.

Key words: Abortion, threatened；, CA-125 antigen；, Forecasting；, Therapy；, Chorionic gonadotropin, beta subunit, human；, Dydrogesterone；, Receptors, progesterone