国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2010, Vol. 29 ›› Issue (4): 274-276.

• 综述 • 上一篇    下一篇

蛋白激酶C对生殖细胞及受精过程的影响

丁玉芹,姜宏   

  1. 230031 合肥，安徽医科大学解放军临床学院生殖 中心
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-07-15 发布日期:2010-07-15
  • 通讯作者: 姜宏

Influence of Protein Kinase C on Germ Cell and Fertilization

DING Yu-qin，JIANG Hong.   

  1. Reproductive Medicine Center，The 105th Hospital of PLA Affiliated Anhui Medical University，Hefei 230031，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2010-07-15 Online:2010-07-15
  • Contact: JIANG Hong

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摘要： 蛋白激酶C（PKC）是一种丝氨酸/ 苏氨酸蛋白激酶，是细胞内多种信号转导通路的重要
成分，参与细胞周期的调控、生长、增殖、分化与凋亡等多种生理过程。研究证明，PKC亚型存在于精子和
卵母细胞中，参与受精过程。因此，了解PKC 的生理作用对探讨弱精子症发生的分子机制、卵母细胞成熟
及受精过程具有重要意义。

关键词: 蛋白激酶C, 精子能动性, 卵母细胞, 受精, 弱精子症

Abstract: Protein kinase C（PKC），as a multifunctional serine/threonine protein kinase and important
component of cell signaling pathways，takes part in many physiological processes in regulating cell cycle，
growth，proliferation，differentiation and apoptosis. It has been proved that isozymes of PKC are expressed in
sperm and oocyte and can participate in fertilization，therefore further understanding has been showed that the
physiological role of PKC would be imperative in exploring molecular mechanism of asthenospermia，oocyte
maturation and fertilization.

Key words: Protein kinase C, Sperm motility, Oocyte, Fertilization, Asthenozoospermia