国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2012, Vol. 31 ›› Issue (5): 344-347.

• 专家论坛 • 上一篇    下一篇

颗粒细胞与卵母细胞发育

沈 浣   

  1. 100044 北京大学人民医院生殖医学中心
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2012-09-15 发布日期:2012-09-15

Granulosa and Oocyte Development

SHEN Huan   

  1. Reproductive Medical Center，People 's Hospital of Peking University，Beijing 100044，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2012-09-15 Online:2012-09-15

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摘要： 颗粒细胞在卵母细胞发育、成熟中起着重要的营养及信号传导作用，同时卵母细胞对颗粒细胞的分化及发育也起着中心调节作用。研究颗粒细胞的基因表达改变可以对卵母细胞发育的微环境进行评估。颗粒细胞基因差异表达可能与卵母细胞质量有关，有可能通过对颗粒细胞基因表达谱的分析，寻找卵母细胞及胚胎选择的生物标记，以提高体外受精的受精率、胚胎种植率及临床妊娠率，降低流产率。

关键词: 卵母细胞, 卵泡, 受精, 体外, 转录, 遗传

Abstract: Granulosa is important in the nutrition and signal transduction for oocyte development andmaturation. Similarly，oocyte also plays regulating roles in the granulosa differentiation and development. Theprofile of gene expression of granulosa may be used to evaluate the micro-environment of oocyte development.The patterns of gene expression of granulosa may be associated with the oocyte quality. Therefore，it is possibleto identify the markers of oocyte and embryo competence by analyzing the granulosa transcriptome, by whichthe IVF fertilization rate, implantation rate and pregnancy rate could be increased, and the miscarriage ratedecreased.

Key words: Oocytes, Ovarian follicle, Fertilization in vitro, Transcription, genetic