国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2014, Vol. 33 ›› Issue (1): 44-47.

• 综述 • 上一篇    下一篇

H19基因在辅助生殖技术领域中的研究进展

严永旭，胡卫华   

  1. 241001 安徽省芜湖市，皖南医学院附属弋矶山医院生殖医学中心
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2014-01-15 发布日期:2014-01-15
  • 通讯作者: 胡卫华

H19 Gene and Its Significance in Assisted Reproductive Technology

YAN Yong-xu，HU Wei-hua   

  1. Department of Reproductive Medicine，Yijishan Hospital，Wannan Medical College，Wuhu 241001，Anhui Province，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2014-01-15 Online:2014-01-15
  • Contact: HU Wei-hua

PDF (PC)

7488

摘要： 辅助生殖技术（ART）虽然已成为人们解决不孕不育的主要手段，但该项技术仍存在一定安全隐患，如经卵胞浆内单精子注射（ICSI）和体外受精-胚胎移植（IVF-ET）获得的胎儿有表观遗传学改变的可能，这些表观遗传学的改变是否对后代造成不利影响，有待进一步深入研究和探讨。H19基因为母源性基因，是最早被鉴定的印迹基因之一。研究显示H19基因变异与胎儿表观遗传学性状改变相关。综述H19基因与ART的关系。

关键词: 生殖技术, 辅助, 不育, 女（雌）性, 基因组印迹, 基因表达调控, H19基因

Abstract: Although assisted reproductive technology （ART） has been widely used in the infertile treatment now，there are potential effects on ART safety，such as the potential changes in epigenetics in ART offspring，especial those ART techniques including ICSI and IVF-ET. It is necessary to study further whether those potential epigenetic changes adversely affect offspings. H19 gene，as a maternal gene，is one of the imprinting genes which were firstly identified. Research showed that H19 gene variation was associated with the epigenetic changes of offspring. In this paper，the relationship between H19 gene and ART safety was reviewed.

Key words: Reproductive techniques, assisted, Infertility, female, Genomic imprinting, Gene expression regulation, H19 gene