国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2016, Vol. 35 ›› Issue (2): 160-164.

• 综述 • 上一篇    下一篇

HMGB1调节Treg细胞参与子宫内膜异位症发病的免疫机制

谢鸿玉，梁炎春，姚书忠   

  1. 510089 广州，中山大学中山医学院临床医学八年制2012级（谢鸿玉）；中山大学附属第一医院妇产科（梁炎春，姚书忠）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2016-03-15 发布日期:2016-03-15
  • 通讯作者: 姚书忠

The Role of HMGB1 in Immunological Pathogenesis of Endometriosis through Regulating Treg Cells

XIE Hong-yu，LIANG Yan-chun，YAO Shu-zhong   

  1. Grade 2012 in 8-year Medical Education Program of Zhongshan School of Medicine，Sun Yat-sen University，Guangzhou 510089，China（XIE Hong-yu）；Department of Obstetrics and Gynecology，The First Affiliated Hospital，Sun Yat-sen University，Guangzhou 510080，China（LIANG Yan-chun，YAO Shu-zhong）
  • Received:1900-01-01 Revised:1900-01-01 Published:2016-03-15 Online:2016-03-15
  • Contact: YAO Shu-zhong

PDF (PC)

7817

摘要： 免疫发病机制是子宫内膜异位症的重要发病机制之一。研究发现，高迁移率族蛋白B1（HMGB1）在子宫内膜异位症中的表达明显升高，其通过影响异位病灶中的炎症反应、新生血管生成、细胞侵袭、转移以及凋亡等参与子宫内膜异位症的发生与发展。调节性T细胞（Treg细胞）也与子宫内膜异位症的发生关系密切，Treg细胞数量以及功能的变化造成子宫内膜异位症患者体内的免疫微环境失调，导致盆腔内免疫功能低下和免疫逃逸的发生，因此促进了异位内膜的种植和生长。越来越多的证据表明，子宫内膜异位症患者体内异常表达的HMGB1可促进Treg细胞的分泌、减少Treg细胞凋亡以及增强Treg细胞介导的免疫抑制作用，参与子宫内膜异位症的免疫发病机制。

关键词: HMGB1蛋白质, T淋巴细胞, 调节性, 子宫内膜异位症

Abstract: Immunological pathogenesis is one of the important mechanisms of endometriosis. Recently，studies show that the over-expressed high mobility group box 1 protein （HMGB1） plays some roles in the development of endometriosis by regulating inflammation，neoangiogenesis，invasiveness，migration and apoptosis of ectopic endometrium. Regulatory T cells （Treg cells） are also closely related to endometriosis. Abnormal amount and dysfunction of Treg cells in endometriosis lead to an imbalanced immunological microenvironment （including immuno-deficiency and immune-escape），promoting the implantation and growth of ectopic endometrium. Growing studies suggest that HMGB1 plays an important role in immunological pathogenesis of endometriosis by enhancing the secretion of Treg cells，reducing apoptosis of Treg cells and strengthening the immunosuppression of Treg cells.

Key words: HMGB1 protein, T-Lymphocytes, regulatory, Endometriosis