关键词: 空气污染物, 生物学标记, 端粒, 线粒体, DNA甲基化

Abstract: Air pollution can lead to respiratory diseases and cardiovascular and cerebrovascular diseases. Pregnant women in a high metabolic state are more sensitive to air pollutants, while the fetuses in a critical period of physiological development are also more sensitive to pollutants. Studies in recent years have shown that the exposure to air pollution is associated with several adverse perinatal outcomes, including spontaneous abortions, intrauterine growth retardation, preterm births, and low birth weight (LBW). However, the underlying mechanism is unclear. At present, many biomarkers of the exposure to air pollution, such as DNA adducts, were screened out by the applications of exposomics and metabonomics. Biomarkers can be used to reflect the level of internal exposure in an individual. It is thought that those biomarkers are more accurate than the monitoring of exposed contaminants. It is important that those biomarkers can be used to explore the potential mechanism of adverse pregnant outcomes related with the exposure to air pollution.

Key words:  Air pollutants, Biological markers;, Telomere, DNA, mitochondrial, DNA methylation