关键词: 卵巢；, 衰老；, RNA；, 卵泡闭锁；, 卵母细胞

Abstract: Ovarian aging refers to the process of gradual decline of ovarian reserve before ovarian failure. The decreasing numbers of follicles and diminished oocyte quality are the main manifestations of ovarian aging, which reduces the ovarian endocrine function and female fertility. The impaired follicular development and accelerated follicle atresia lead to a decrease in the number of follicles, while the decline of oocyte quality is related to the disorder of DNA damage-repair, oxidative stress and the dysfunction of mitochondria. Although the mechanism of ovarian aging is still unclear, recent studies have found that non-coding RNAs (ncRNA) as a group of functional RNA molecules participate in the regulation of ovarian function, especially in the differentiation, proliferation and apoptosis of ovarian cells. NcRNAs participate in the occurrence of ovarian aging by affecting follicular development and atresia, the synthesis and secretion of ovarian hormones. With the development of science and technology, more and more mechanisms of ncRNA in regulating ovarian aging will be discovered, providing new ideas for the diagnosis and treatment of ovarian aging. This review focuses on the research progress of ncRNAs in ovarian aging.

Key words: Ovary；Aging；, RNA；, Follicular atresia；, Oocytes