维生素D对辅助生殖技术助孕结局的影响

doi:10.12280/gjszjk.20210609

摘要/Abstract

摘要：

维生素D除了作为类固醇激素参与钙磷代谢、维持骨质稳态外,也可作为生殖激素发挥作用。在女性体内,维生素D参与卵泡生成、卵巢性激素的产生,从而影响卵巢储备功能;在男性体内,可影响精液质量和精子活力。维生素D受体在两性生殖器官中广泛表达,可通过多种作用机制影响辅助生殖技术助孕夫妇的生育力及其妊娠结局。然而当前对不孕患者通过辅助生殖技术助孕时,外源性补充维生素D能否改善其妊娠结局的意见尚不统一。综述维生素D对两性生殖功能的影响,并讨论维生素D能否改善辅助生殖技术助孕结局。

关键词: 维生素D, 生育力, 生殖技术, 辅助, 妊娠结局, 卵巢储备功能

Abstract:

Vitamin D not only participates in the calcium and phosphorus metabolism and the skeletal homeostasis as a steroid hormone, but also plays a role as a reproductive hormone. In women, vitamin D is involved in follicular formation and the production of ovarian sex hormones, which affects ovarian reserve function. In men, it can affect semen quality and sperm motility. Vitamin D receptor is widely expressed in the reproductive organs of both sexes, which can affect the fertility and pregnancy outcome of assisted reproductive technology through a variety of mechanisms. However, there is no consensus on whether exogenous vitamin D supplementation improves pregnancy outcomes of infertile patients undergoing assisted reproductive technology. This paper reviews the effect of vitamin D on male and female reproductive function, and discusses whether vitamin D can improve the outcome of assisted reproductive technology.

Key words: Vitamin D, Fertility, Reproductive techniques, assisted, Pregnancy outcome, Ovarian reserve

王青娣, 熊正方. 维生素D对辅助生殖技术助孕结局的影响[J]. 国际生殖健康/计划生育, 2022, 41(2): 143-146.

WANG Qing-di, XIONG Zheng-fang. Effect of Vitamin D on Outcomes of Assisted Reproduction Technology[J]. Journal of International Reproductive Health/Family Planning, 2022, 41(2): 143-146.

参考文献 31

[1]	Holick MF. Vitamin D deficiency[J]. N Engl J Med, 2007, 357(3):266-281. doi: 10.1056/NEJMra070553. doi: 10.1056/NEJMra070553 URL
[2]	Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation,treatment,and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline[J]. J Clin Endocrinol Metab, 2011, 96(7):1911-1930. doi: 10.1210/jc.2011-0385. doi: 10.1210/jc.2011-0385 URL
[3]	Shahrokhi SZ, Ghaffari F, Kazerouni F. Role of vitamin D in female reproduction[J]. Clin Chim Acta, 2016, 455:33-38. doi: 10.1016/j.cca.2015.12.040. doi: 10.1016/j.cca.2015.12.040 pmid: 26747961
[4]	Blomberg Jensen M, Nielsen JE, Jørgensen A, et al. Vitamin D receptor and vitamin D metabolizing enzymes are expressed in the human male reproductive tract[J]. Hum Reprod, 2010, 25(5):1303-1311. doi: 10.1093/humrep/deq024. doi: 10.1093/humrep/deq024 URL
[5]	Yao X, Wang Z, El-Samahy MA, et al. Roles of vitamin D and its receptor in the proliferation and apoptosis of luteinised granulosa cells in the goat[J]. Reprod Fertil Dev, 2020, 32(3):335-348. doi: 10.1071/RD18442. doi: 10.1071/RD18442 URL
[6]	Merhi Z, Doswell A, Krebs K, et al. Vitamin D alters genes involved in follicular development and steroidogenesis in human cumulus granulosa cells[J]. J Clin Endocrinol Metab, 2014, 99(6):E1137-E1145. doi: 10.1210/jc.2013-4161. doi: 10.1210/jc.2013-4161 URL
[7]	Arefi S, Khalili G, Iranmanesh H, et al. Is the ovarian reserve influenced by vitamin D deficiency and the dress code in an infertile Iranian population?[J]. J Ovarian Res, 2018, 11(1):62. doi: 10.1186/s13048-018-0435-7. doi: 10.1186/s13048-018-0435-7 URL
[8]	Naderi Z, Kashanian M, Chenari L, et al. Evaluating the effects of administration of 25-hydroxyvitamin D supplement on serum anti-mullerian hormone (AMH) levels in infertile women[J]. Gynecol Endocrinol, 2018, 34(5):409-412. doi: 10.1080/09513590.2017. 1410785. doi: 10.1080/09513590.2017.1410785 pmid: 29212401
[9]	李施施, 张岭, 姬萌霞, 等. 卵巢储备功能评估指标与维生素D的相关性分析[J]. 预防医学, 2020, 32(8):828-831. doi: 10.19485/j.cnki.issn2096-5087.2020.08.017. doi: 10.19485/j.cnki.issn2096-5087.2020.08.017
[10]	Drakopoulos P, van de Vijver A, Schutyser V, et al. The effect of serum vitamin D levels on ovarian reserve markers: a prospective cross-sectional study[J]. Hum Reprod, 2017, 32(1):208-214. doi: 10.1093/humrep/dew304. doi: 10.1093/humrep/dew304
[11]	Karimi E, Arab A, Rafiee M, et al. A systematic review and meta-analysis of the association between vitamin D and ovarian reserve[J]. Sci Rep, 2021, 11(1):16005. doi: 10.1038/s41598-021-95481-x. doi: 10.1038/s41598-021-95481-x URL
[12]	Reginatto MW, Pizarro BM, Antunes RA, et al. Vitamin D receptor taqi polymorphism is associated with reduced follicle number in women utilizing assisted reproductive technologies[J]. Front Endocrinol (Lausanne), 2018, 9:252. doi: 10.3389/fendo.2018.00252. doi: 10.3389/fendo.2018.00252 URL
[13]	Malloy PJ, Peng L, Wang J, et al. Interaction of the vitamin D receptor with a vitamin D response element in the Mullerian-inhibiting substance (MIS) promoter: regulation of MIS expression by calcitriol in prostate cancer cells[J]. Endocrinology, 2009, 150(4):1580-1587. doi: 10.1210/en.2008-1555. doi: 10.1210/en.2008-1555 pmid: 19056816
[14]	Walz NL, Hinchliffe PM, Soares MJ, et al. Serum Vitamin D status is associated with increased blastocyst development rate in women undergoing IVF[J]. Reprod BioMed Online, 2020, 41(6):1101-1111. doi: 10.1016/j.rbmo.2020.08.014. doi: 10.1016/j.rbmo.2020.08.014 URL
[15]	Hosseinirad H, Novin MG, Hosseini S, et al. Effect of 1, 25(OH)₂-vitamin D3 on expression and phosphorylation of progesterone receptor in cultured endometrial stromal cells of patients with repeated implantation failure[J]. Acta Histochem, 2020, 122(2):151489. doi: 10.1016/j.acthis.2019.151489. doi: S0065-1281(19)30479-9 pmid: 31879032
[16]	Fabris AM, Cruz M, Iglesias C, et al. Impact of vitamin D levels on ovarian reserve and ovarian response to ovarian stimulation in oocyte donors[J]. Reprod Biomed Online, 2017, 35(2):139-144. doi: 10.1016/j.rbmo.2017.05.009. doi: 10.1016/j.rbmo.2017.05.009 URL
[17]	Ikemoto Y, Kuroda K, Nakagawa K, et al. Vitamin D regulates maternal T-helper cytokine production in infertile women[J]. Nutrients, 2018, 10(7):902. doi: 10.3390/nu10070902. doi: 10.3390/nu10070902 URL
[18]	Chen W, Jiao X, Zhang J, et al. Vitamin D deficiency and high serum IL-6 concentration as risk factors for tubal factor infertility in Chinese women[J]. Nutrition, 2018, 49:24-31. doi: 10.1016/j.nut.2017.11.016. doi: 10.1016/j.nut.2017.11.016 URL
[19]	Aramesh S, Alifarja T, Jannesar R, et al. Does vitamin D supplementation improve ovarian reserve in women with diminished ovarian reserve and vitamin D deficiency: a before-and-after intervention study[J]. BMC Endocri ne Disord, 2021, 21(1):126. doi: 10.1186/s12902-021-00786-7. doi: 10.1186/s12902-021-00786-7
[20]	He J, Wang H, Shi J, et al. 1, 25-Dihydroxyvitamin D deficiency accelerates male reproductive senescence in aging mice and 1, 25 (OH) 2D3 alleviates oxidative stress via NF-κB/SOD[J]. Am J Physiol Endocrinol Metab, 2021, 320(4):E732-E746. doi: 10.1152/ajpendo.00531.2020. doi: 10.1152/ajpendo.00531.2020 URL
[21]	Rehman R, Lalani S, Baig M, et al. Association between vitamin D, reproductive hormones and sperm parameters in infertile male subjects[J]. Front Endocrinol(Lausanne), 2018, 9:607. doi: 10.3389/fendo.2018.00607. doi: 10.3389/fendo.2018.00607
[22]	Jueraitetibaike K, Ding Z, Wang DD, et al. The effect of vitamin D on sperm motility and the underlying mechanism[J]. Asian J Androl, 2019, 21(4):400-407. doi: 10.4103/aja.aja_105_18. doi: 10.4103/aja.aja_105_18 pmid: 30618415
[23]	Bøllehuus Hansen L, Rehfeld A, de Neergaard R, et al. Selection of high-quality spermatozoa may be promoted by activated vitamin D in the woman[J]. J Clin Endocrinol Metab, 2017, 102(3):950-961. doi: 10.1210/jc.2016-3008. doi: 10.1210/jc.2016-3008 pmid: 27977320
[24]	Blomberg Jensen M, Lawaetz JG, Petersen JH, et al. Effects of vitamin D supplementation on semen quality,reproductive hormones,and live birth rate: a randomized clinical trial[J]. J Clin Endocrinol Metab, 2018, 103(3):870-881. doi: 10.1210/jc.2017-01656. doi: 10.1210/jc.2017-01656 pmid: 29126319
[25]	Banks N, Sun F, Krawetz SA, et al. Male vitamin D status and male factor infertility[J]. Fertil Steril, 2021, 116(4):973-979. doi: 10.1016/j.fertnstert.2021.06.035. doi: 10.1016/j.fertnstert.2021.06.035 URL
[26]	Cozzolino M, Busnelli A, Pellegrini L, et al. How vitamin D level influences in vitro fertilization outcomes: results of a systematic review and meta-analysis[J]. Fertil Steril, 2020, 114(5):1014-1025. doi: 10.1016/j.fertnstert.2020.05.040. doi: 10.1016/j.fertnstert.2020.05.040 pmid: 33012554
[27]	Somigliana E, Sarais V, Reschini M, et al. Single oral dose of vitamin D3 supplementation prior to in vitro fertilization and embryo transfer in normal weight women: the SUNDRO randomized controlled trial[J]. Am J Obstet Gynecol, 2021, 225(3):283.e1-283.e10. doi: 10.1016/j.ajog.2021.04.234. doi: 10.1016/j.ajog.2021.04.234
[28]	Jiang L, Ji L, Song J, et al. The effect of serum vitamin D levels in couples on embryo development and clinical outcomes[J]. Reprod Biomed Online, 2019, 38(5):699-710. doi: 10.1016/j.rbmo.2018. 12.036. doi: S1472-6483(18)30665-5 pmid: 30772193
[29]	Liu X, Zhang W, Xu Y, et al. Effect of vitamin D status on normal fertilization rate following in vitro fertilization[J]. Reprod Biol Endocrinol, 2019, 17(1):59. doi: 10.1186/s12958-019-0500-0. doi: 10.1186/s12958-019-0500-0 URL
[30]	Wu L, Kwak-Kim J, Zhang R, et al. Vitamin D level affects IVF outcome partially mediated via Th/Tc cell ratio[J]. Am J Reprod Immunol, 2018, 80(6):e13050. doi: 10.1111/aji.13050. doi: 10.1111/aji.13050 URL
[31]	Muyayalo KP, Song S, Zhai H, et al. Low vitamin D levels in follicular fluid, but not in serum, are associated with adverse outcomes in assisted reproduction[J]. Arch Gynecol Obstet, 2021 Aug 8. doi: 10.1007/s00404-021-06174-9. Epub ahead of print. doi: 10.1007/s00404-021-06174-9