昼夜节律紊乱对女性卵巢功能的影响

doi:10.12280/gjszjk.20220089

摘要/Abstract

摘要：

昼夜节律是一种内源性的计时机制,可以调控人体所需的睡眠、饮食和生殖节律等。随着生活、工作模式的改变,昼夜节律紊乱已成为普遍关注的健康问题。卵巢功能反映卵巢皮质区基础卵泡生长发育的能力,包括卵泡的数量和质量,反映了女性的生育潜能。研究表明,昼夜节律与卵巢功能存在相关性。昼夜节律紊乱通过改变生殖激素的分泌、排卵、卵母细胞数量、褪黑素水平和时钟基因的表达影响卵巢功能。综述昼夜节律紊乱对卵巢功能的影响,为临床的研究及诊疗方向提供思路。

关键词: 昼夜节律, 卵巢储备功能, 性腺甾类激素, 排卵, 卵母细胞, 褪黑激素

Abstract:

Circadian rhythm as an endogenous timing mechanism regulates the sleep, diet and reproductive rhythm of human body. With the changes of life and work patterns, the disorder of circadian rhythm has become a health problem of general concern. Ovarian function reflects the growth and development ability of basic follicles in ovarian cortex, including the number and quality of follicles, and reflects women′s reproductive potential. More and more studies have shown that there is a correlation between circadian rhythm and ovarian function. Circadian rhythm disorder affects ovarian function by changing the secretion of reproductive hormones, ovulation, the number of oocytes, the level of melatonin and the expression of clock genes. This review expounds the influence of circadian rhythm disorder on ovarian function, so as to provide ideas for clinical research and diagnosis and treatment.

Key words: Circadian rhythm, Ovarian reserve, Gonadal steroid hormones, Ovulation, Oocytes, Melatonin

王子昕, 宋佳怡, 夏天. 昼夜节律紊乱对女性卵巢功能的影响[J]. 国际生殖健康/计划生育, 2022, 41(4): 317-321.

WANG Zi-xin, SONG Jia-yi, XIA Tian. Effect of Circadian Rhythm Disorder on Ovarian Function[J]. Journal of International Reproductive Health/Family Planning, 2022, 41(4): 317-321.

参考文献 40

[1]	Zhang WX, Chen SY, Liu C. Regulation of reproduction by the circadian rhythms[J]. Acta Physiologica Sinica, 2016, 68(6):799-808. doi: 10.13294/j.aps.2016.0089. doi: 10.13294/j.aps.2016.0089
[2]	Zheng Y, Liu C, Li Y, et al. Loss-of-function mutations with circadian rhythm regulator Per1/Per2 lead to premature ovarian insufficiency[J]. Biol Reprod, 2019, 100(4):1066-1072. doi: 10.1093/biolre/ioy245. doi: 10.1093/biolre/ioy245 URL
[3]	Li H, Liu M, Zhang C. Women with polycystic ovary syndrome (PCOS) have reduced melatonin concentrations in their follicles and have mild sleep disturbances[J]. BMC Womens Health, 2022, 22(1):79. doi: 10.1186/s12905-022-01661-w. doi: 10.1186/s12905-022-01661-w URL
[4]	Wang F, Xie N, Wu Y, et al. Association between circadian rhythm disruption and polycystic ovary syndrome[J]. Fertil Steril, 2021, 115(3):771-781. doi: 10.1016/j.fertnstert.2020.08.1425. doi: 10.1016/j.fertnstert.2020.08.1425 URL
[5]	Ohara T, Nakamura TJ, Nakamura W, et al. Modeling circadian regulation of ovulation timing: age-related disruption of estrous cyclicity[J]. Sci Rep, 2020, 10(1):16767. doi: 10.1038/s41598-020-73669-x. doi: 10.1038/s41598-020-73669-x URL
[6]	白会强, 吴建涛, 王勇, 等. 睡眠障碍的中西医诊疗进展[J]. 中国社区医师, 2020, 36(26):7-8. doi: 10.3969/j.issn.1007-614x.2020.26.003. doi: 10.3969/j.issn.1007-614x.2020.26.003
[7]	Yaw AM, McLane-Svoboda AK, Hoffmann HM. Shiftwork and Light at Night Negatively Impact Molecular and Endocrine Timekeeping in the Female Reproductive Axis in Humans and Rodents[J]. Int J Mol Sci, 2020, 22(1):324. doi: 10.3390/ijms22010324. doi: 10.3390/ijms22010324 URL
[8]	Pimolsri C, Lyu X, Goldstein C, et al. Objective sleep duration and timing predicts completion of in vitro fertilization cycle[J]. J Assist Reprod Genet, 2021, 38(10):2687-2696. doi: 10.1007/s10815-021-02260-8. doi: 10.1007/s10815-021-02260-8 URL
[9]	Zhang L, Liu Y, Li M, et al. Effect of a high-calorie diet and constant light exposure on female reproduction, metabolism and immune inflammation: A comparative study of different mouse models[J]. Am J Reprod Immunol, 2021, 86(5):e13479. doi: 10.1111/aji.13479. doi: 10.1111/aji.13479
[10]	Sciarra F, Franceschini E, Campolo F, et al. Disruption of Circadian Rhythms: A Crucial Factor in the Etiology of Infertility[J]. Int J Mol Sci, 2020, 21(11):3943. doi: 10.3390/ijms21113943. doi: 10.3390/ijms21113943 URL
[11]	Michels KA, Mendola P, Schliep KC, et al. The influences of sleep duration, chronotype, and nightwork on the ovarian cycle[J]. Chronobiol Int, 2020, 37(2):260-271. doi: 10.1080/07420528.2019.1694938. doi: 10.1080/07420528.2019.1694938 pmid: 31778080
[12]	Mahoney MM. Shift work, jet lag, and female reproduction[J]. Int J Endocrinol, 2010, 2010:813764. doi: 10.1155/2010/813764. doi: 10.1155/2010/813764
[13]	Leysen V, Prevot V. Reproductive Function During Chronodisruption: Model of Shiftwork in Rodents[J]. Endocrinology, 2020, 161(12):bqaa151. doi: 10.1210/endocr/bqaa151. doi: 10.1210/endocr/bqaa151 URL
[14]	Merklinger-Gruchala A, Ellison PT, Lipson SF, et al. Low estradiol levels in women of reproductive age having low sleep variation[J]. Eur J Cancer Prev, 2008, 17(5):467-472. doi: 10.1097/CEJ.0b013e3282f75f67. doi: 10.1097/CEJ.0b013e3282f75f67 pmid: 18714190
[15]	陈昌钊, 吴汤娜, 符叶柳, 等. 女性基础性激素、抗苗勒管激素水平联合经阴道三维超声在卵巢储备功能评估中的作用[J]. 中华医学超声杂志(电子版), 2020, 17(12):1208-1212. doi: 10.3877/cma.j.issn.1672-6448.2020.12.012. doi: 10.3877/cma.j.issn.1672-6448.2020.12.012
[16]	Bungum L, Jacobsson AK, Rosén F, et al. Circadian variation in concentration of anti-Müllerian hormone in regularly menstruating females: relation to age, gonadotrophin and sex steroid levels[J]. Hum Reprod, 2011, 26(3):678-684. doi: 10.1093/humrep/deq380. doi: 10.1093/humrep/deq380 URL
[17]	Zheng M, Zuo G, Tong J, et al. Intrafollicular melatonin concentration is elevated in patients with ovarian hyperstimulation syndrome (OHSS) and can serve as an important predictor of OHSS[J]. Arch Gynecol Obstet, 2019, 299(4):1151-1158. doi: 10.1007/s00404-018-4994-z. doi: 10.1007/s00404-018-4994-z pmid: 30725184
[18]	Komada Y, Ikeda Y, Sato M, et al. Social jetlag and menstrual symptoms among female university students[J]. Chronobiol Int, 2019, 36(2):258-264. doi: 10.1080/07420528.2018.1533561. doi: 10.1080/07420528.2018.1533561 pmid: 30395733
[19]	Stock D, Knight JA, Raboud J, et al. Rotating night shift work and menopausal age[J]. Hum Reprod, 2019, 34(3): 539-548. doi: 10.1093/humrep/dey390. doi: 10.1093/humrep/dey390
[20]	Willis SK, Hatch EE, Wise LA. Sleep and female reproduction[J]. Curr Opin Obstet Gynecol, 2019, 31(4):222-227. doi: 10.1097/GCO.0000000000000554. doi: 10.1097/GCO.0000000000000554 URL
[21]	Li Y, Cheng S, Li L, et al. Light-exposure at night impairs mouse ovary development via cell apoptosis and DNA damage[J]. Biosci Rep, 2019, 39(5):BSR20181464. doi: 10.1042/BSR20181464. doi: 10.1042/BSR20181464 URL
[22]	Mínguez-Alarcón L, Souter I, Williams PL, et al. Occupational factors and markers of ovarian reserve and response among women at a fertility centre[J]. Occup Environ Med, 2017, 74(6):426-431. doi: 10.1136/oemed-2016-103953. doi: 10.1136/oemed-2016-103953 pmid: 28167499
[23]	Goldstein CA, Lanham MS, Smith YR, et al. Sleep in women undergoing in vitro fertilization: a pilot study[J]. Sleep Med, 2017, 32:105-113. doi: 10.1016/j.sleep.2016.12.007. doi: S1389-9457(16)30321-5 pmid: 28366321
[24]	Rai S, Ghosh H. Modulation of human ovarian function by melatonin[J]. Front Biosci(Elite Ed), 2021, 13(1):140-157. doi: 10.2741/875. doi: 10.2741/875
[25]	Zheng M, Tong J, Li WP, et al. Melatonin concentration in follicular fluid is correlated with antral follicle count (AFC) and in vitro fertilization (IVF) outcomes in women undergoing assisted reproductive technology (ART) procedures[J]. Gynecol Endocrinol, 2018, 34(5):446-450. doi: 10.1080/09513590.2017.1409713. doi: 10.1080/09513590.2017.1409713 pmid: 29185361
[26]	Latif Khan H, Bhatti S, Latif Khan Y, et al. Cell-free nucleic acids and melatonin levels in human follicular fluid predict embryo quality in patients undergoing in-vitro fertilization treatment[J]. J Gynecol Obstet Hum Reprod, 2020, 49(1):101624. doi: 10.1016/j.jogoh.2019.08.007. doi: 10.1016/j.jogoh.2019.08.007 URL
[27]	Hu KL, Ye X, Wang S, et al. Melatonin Application in Assisted Reproductive Technology: A Systematic Review and Meta-Analysis of Randomized Trials[J]. Front Endocrinol(Lausanne), 2020, 11:160. doi: 10.3389/fendo.2020.00160. doi: 10.3389/fendo.2020.00160
[28]	Touitou Y, Reinberg A, Touitou D. Association between light at night, melatonin secretion, sleep deprivation, and the internal clock: Health impacts and mechanisms of circadian disruption[J]. Life Sci, 2017, 173:94-106. doi: 10.1016/j.lfs.2017.02.008. doi: S0024-3205(17)30045-0 pmid: 28214594
[29]	Li Y, Liu H, Wu K, et al. Melatonin promotes human oocyte maturation and early embryo development by enhancing clathrin-mediated endocytosis[J]. J Pineal Res, 2019, 67(3):e12601. doi: 10.1111/jpi.12601. doi: 10.1111/jpi.12601
[30]	Brzezinski A, Rai S, Purohit A, et al. Melatonin, Clock Genes, and Mammalian Reproduction: What Is the Link?[J]. Int J Mol Sci, 2021, 22(24):13240. doi: 10.3390/ijms222413240. doi: 10.3390/ijms222413240 URL
[31]	Razavi P, Devore EE, Bajaj A, et al. Shift Work, Chronotype, and Melatonin Rhythm in Nurses[J]. Cancer Epidemiol Biomarkers Prev, 2019, 28(7):1177-1186. doi: 10.1158/1055-9965.EPI-18-1018. doi: 10.1158/1055-9965.EPI-18-1018 URL
[32]	Shao S, Zhao H, Lu Z, et al. Circadian Rhythms Within the Female HPG Axis: From Physiology to Etiology[J]. Endocrinology, 2021, 162(8):bqab117. doi: 10.1210/endocr/bqab117. doi: 10.1210/endocr/bqab117 URL
[33]	Sen A, Hoffmann HM. Role of core circadian clock genes in hormone release and target tissue sensitivity in the reproductive axis[J]. Mol Cell Endocrinol, 2020, 501:110655. doi: 10.1016/j.mce.2019.110655. doi: 10.1016/j.mce.2019.110655 URL
[34]	Jiang Z, Zou K, Liu X, et al. Aging attenuates the ovarian circadian rhythm[J]. J Assist Reprod Genet, 2021, 38(1):33-40. doi: 10.1007/s10815-020-01943-y. doi: 10.1007/s10815-020-01943-y URL
[35]	Sun SY, Chen GH. Treatment of Circadian Rhythm Sleep-Wake Disorders[J]. Curr Neuropharmacol, 2022, 20(6):1022-1034. doi: 10.2174/1570159X19666210907122933. doi: 10.2174/1570159X19666210907122933 URL
[36]	Moon E, Partonen T, Beaulieu S, et al. Melatonergic agents influence the sleep-wake and circadian rhythms in healthy and psychiatric participants: a systematic review and meta-analysis of randomized controlled trials[J]. Neuropsychopharmacology, 2022 Feb 4. doi: 10.1038/s41386-022-01278-5. doi: 10.1038/s41386-022-01278-5
[37]	Lim S, Park S, Koyanagi A, et al. Effects of exogenous melatonin supplementation on health outcomes: An umbrella review of meta-analyses based on randomized controlled trials[J]. Pharmacol Res, 2022, 176:106052. doi: 10.1016/j.phrs.2021.106052. doi: 10.1016/j.phrs.2021.106052 URL
[38]	Yang C, Liu Q, Chen Y, et al. Melatonin delays ovarian aging in mice by slowing down the exhaustion of ovarian reserve[J]. Commun Biol, 2021, 4(1):534. doi: 10.1038/s42003-021-02042-z. doi: 10.1038/s42003-021-02042-z URL
[39]	Li S, Zhai J, Chu W, et al. Altered circadian clock as a novel therapeutic target for constant darkness-induced insulin resistance and hyperandrogenism of polycystic ovary syndrome[J]. Transl Res, 2020, 219:13-29. doi: 10.1016/j.trsl.2020.02.003. doi: 10.1016/j.trsl.2020.02.003 URL
[40]	Li C, Xing C, Zhang J, et al. Eight-hour time-restricted feeding improves endocrine and metabolic profiles in women with anovulatory polycystic ovary syndrome[J]. J Transl Med, 2021, 19(1):148. doi: 10.1186/s12967-021-02817-2. doi: 10.1186/s12967-021-02817-2 URL