Research Progress on PGC-1α in Ovary

doi:10.12280/gjszjk.20200254

Abstract

Abstract:

Peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α), an important nuclear transcription coactivator, is a key regulator of mitochondrial production. PGC-1α is involved in various biological processes such as mitochondrial biosynthesis, adaptive thermogenesis, energy metabolism, apoptosis induction, cellular signal transduction and tumorigenesis through interaction with nuclear receptors and transcription factors. In recent years, many studies have shown that PGC-1α participats in the follicular development and atresia, and ovarian hormones synthesis and secretion. The abnormal expression of PGC-1α can result in reproductive and endocrine problems and disorder, such as diminished ovarian reserve, polycystic ovary syndrome and ovarian neoplasms. With the continuous in-depth study, the mechanism of PGC-1α in the regulation of ovarian function will be discovered. This review briefly summarized the function of PGC-1α in ovary and research progress, which may provide new reference for the diagnosis and treatment of some ovarian diseases.

Key words: Peroxisome proliferator-activated receptor gamma coactivator 1 alpha, Ovary, Ovarian follicle, Follicular atresia, Signal transduction, Polycystic ovary syndrome, Ovarian neoplasms

GE Ting, YANG Xiao-kui. Research Progress on PGC-1α in Ovary[J]. Journal of International Reproductive Health/Family Planning, 2021, 40(2): 142-146.

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