Journal of International Reproductive Health/Family Planning

Journal of International Reproductive Health/Family Planning ›› 2010, Vol. 29 ›› Issue (4): 277-280.

• 综述 • Previous Articles     Next Articles

Review of in Vitro Embryotoxicity Screening Methods

WANG Ya-nan，SONG Dian-rong   

  1. Tianjin University of Traditional Chinese Medicine Tianjin 300193, China（WANG Ya-nan）；Department of Gynaecology，the Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine，Tianjin 300150，China （SONG Dian-rong）
  • Received:1900-01-01 Revised:1900-01-01 Published:2010-07-15 Online:2010-07-15

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Abstract: Embryotoxicity tests in vitro, with more than 30 screening methods, are applied on
screening embryotoxicity and developmental toxicity widely. Three effectiveness screening tests recommended
by the European Center for the Validation of Alternative Methods（ECVAM）showed good value of application,
which are whole embryo culture（WEC）、embryonic cell micromass culture（MM）and embryonic stem cell test
（EST）. This article reviews recent progress of embryotoxicity testing in vitro.

Key words: Embryonic development, Toxicity tests, Embryonic stem cells, Teratogens, Limb bud micromass culture, In vitro test