Research Progress in Metabolomics of Mammalian Follicles

doi:10.12280/gjszjk.20210203

Abstract

Abstract:

The oocyte quality is one of the determining factors of successful assisted reproductive technology(ART) outcome. It is beneficial to establish a simple and reliable evaluation system of oocyte quality for improving the success rate of ART. Newly developed metabolomics is expected to provide a new method for evaluating oocyte quality. At present, metabolomics has been used in many relevant studies of female reproduction. By the qualitative and quantitative analysis of small and medium-sized molecules in oocytes, granulosa cells and follicular fluid samples, researchers have identified a variety of symbolic metabolites related to female infertility, which are involved in the metabolism of carbohydrate, lipid, amino acid and other substances. These studies have showed the potential application of metabolomics in the diagnosis and treatment of infertility. We review the research progress in the metabolomics of mammalian follicles.

Key words: Metabolomics, Oocytes, Follicular fluid, Cumulus cells, Biomarkers

MAO Fei, FENG Rui-zhi, QIAN Yun. Research Progress in Metabolomics of Mammalian Follicles[J]. Journal of International Reproductive Health/Family Planning, 2021, 40(6): 471-475.

References 39

[1]	Laisk T, Tšuiko O, Jatsenko T, et al. Demographic and evolutionary trends in ovarian function and aging[J]. Hum Reprod Update, 2019, 25(1):34-50. doi: 10.1093/humupd/dmy031. doi: 10.1093/humupd/dmy031
[2]	Zhou Z, Zheng D, Wu H, et al. Epidemiology of infertility in China: a population-based study[J]. BJOG, 2018, 125(4):432-441. doi: 10.1111/1471-0528.14966. doi: 10.1111/1471-0528.14966 URL
[3]	Montani DA, Braga D, Borges E Jr, et al. Understanding mechanisms of oocyte development by follicular fluid lipidomics[J]. J Assist Reprod Genet, 2019, 36(5):1003-1011. doi: 10.1007/s10815-019-01428-7. doi: 10.1007/s10815-019-01428-7 URL
[4]	Castiglione Morelli MA, Iuliano A, Schettini S, et al. NMR metabolic profiling of follicular fluid for investigating the different causes of female infertility: a pilot study[J]. Metabolomics, 2019, 15(2):19. doi: 10.1007/s11306-019-1481-x. doi: 10.1007/s11306-019-1481-x pmid: 30830455
[5]	Li L, Zhu S, Shu W, et al. Characterization of Metabolic Patterns in Mouse Oocytes during Meiotic Maturation[J]. Mol Cell, 2020, 80(3):525-540.e9. doi: 10.1016/j.molcel.2020.09.022. doi: 10.1016/j.molcel.2020.09.022 URL
[6]	Guijas C, Montenegro-Burke JR, Warth B, et al. Metabolomics activity screening for identifying metabolites that modulate phenotype[J]. Nat Biotechnol, 2018, 36(4):316-320. doi: 10.1038/nbt.4101. doi: 10.1038/nbt.4101 URL
[7]	Rajska A, Buszewska-Forajta M, Rachoń D, et al. Metabolomic Insight into Polycystic Ovary Syndrome-An Overview[J]. Int J Mol Sci, 2020, 21(14):4853. doi: 10.3390/ijms21144853. doi: 10.3390/ijms21144853 URL
[8]	Khan R, Jiang X, Hameed U, et al. Role of Lipid Metabolism and Signaling in Mammalian Oocyte Maturation, Quality, and Acquisition of Competence[J]. Front Cell Dev Biol, 2021, 9:639704. doi: 10.3389/fcell.2021.639704. doi: 10.3389/fcell.2021.639704 URL
[9]	Fontana J, Martínková S, Petr J, et al. Metabolic cooperation in the ovarian follicle[J]. Physiol Res, 2020, 69(1):33-48. doi: 10.33549/physiolres.934233. doi: 10.33549/physiolres.934233 pmid: 31854191
[10]	Uhde K, van Tol H, Stout T, et al. Metabolomic profiles of bovine cumulus cells and cumulus-oocyte-complex-conditioned medium during maturation in vitro[J]. Sci Rep, 2018, 8(1):9477. doi: 10.1038/s41598-018-27829-9. doi: 10.1038/s41598-018-27829-9 URL
[11]	Yang J, Feng T, Li S, et al. Human follicular fluid shows diverse metabolic profiles at different follicle developmental stages[J]. Reprod Biol Endocrinol, 2020, 18(1):74. doi: 10.1186/s12958-020-00631-x. doi: 10.1186/s12958-020-00631-x URL
[12]	Agarwal A, Sengupta P, Durairajanayagam D. Role of L-carnitine in female infertility[J]. Reprod Biol Endocrinol, 2018, 16(1):5. doi: 10.1186/s12958-018-0323-4. doi: 10.1186/s12958-018-0323-4 URL
[13]	Giorgi VS, Da Broi MG, Paz CC, et al. N-Acetyl-Cysteine and l-Carnitine Prevent Meiotic Oocyte Damage Induced by Follicular Fluid From Infertile Women With Mild Endometriosis[J]. Reprod Sci, 2016, 23(3):342-351. doi: 10.1177/1933719115602772. doi: 10.1177/1933719115602772 URL
[14]	Jiang W, Li Y, Zhao Y, et al. l-carnitine supplementation during in vitro culture regulates oxidative stress in embryos from bovine aged oocytes[J]. Theriogenology, 2020, 143:64-73. doi: 10.1016/j.theriogenology.2019.11.036. doi: 10.1016/j.theriogenology.2019.11.036 URL
[15]	Kalhori Z, Mehranjani MS, Azadbakht M, et al. L-Carnitine improves endocrine function and folliculogenesis by reducing inflammation, oxidative stress and apoptosis in mice following induction of polycystic ovary syndrome[J]. Reprod Fertil Dev, 2019, 31(2):282-293. doi: 10.1071/RD18131. doi: 10.1071/RD18131 URL
[16]	Kitano Y, Hashimoto S, Matsumoto H, et al. Oral administration of l-carnitine improves the clinical outcome of fertility in patients with IVF treatment[J]. Gynecol Endocrinol, 2018, 34(8):684-688. doi: 10.1080/09513590.2018.1431769. doi: 10.1080/09513590.2018.1431769 pmid: 29378447
[17]	Zhang H, McClatchie T, Baltz JM. l-Serine transport in growing and maturing mouse oocytes[J]. J Cell Physiol, 2020, 235(11):8585-8600. doi: 10.1002/jcp.29702. doi: 10.1002/jcp.29702 pmid: 32329057
[18]	Xie HL, Zhu S, Zhang J, et al. Glucose metabolism during in vitro maturation of mouse oocytes: An study using RNA interference[J]. J Cell Physiol, 2018, 233(9):6952-6964. doi: 10.1002/jcp.26484. doi: 10.1002/jcp.26484 URL
[19]	Walter J, Huwiler F, Fortes C, et al. Analysis of the equine "cumulome" reveals major metabolic aberrations after maturation in vitro[J]. BMC Genomics, 2019, 20(1):588. doi: 10.1186/s12864-019-5836-5. doi: 10.1186/s12864-019-5836-5 URL
[20]	Cetica P, Pintos L, Dalvit G, et al. Involvement of enzymes of amino acid metabolism and tricarboxylic acid cycle in bovine oocyte maturation in vitro[J]. Reproduction, 2003, 126(6):753-763. pmid: 14748694
[21]	Rosen MP, Shen S, Dobson AT, et al. A quantitative assessment of follicle size on oocyte developmental competence[J]. Fertil Steril, 2008, 90(3):684-690. doi: 10.1016/j.fertnstert.2007.02.011. doi: 10.1016/j.fertnstert.2007.02.011 URL
[22]	Wirleitner B, Okhowat J, Vištejnová L, et al. Relationship between follicular volume and oocyte competence, blastocyst development and live-birth rate: optimal follicle size for oocyte retrieval[J]. Ultrasound Obstet Gynecol, 2018, 51(1):118-125. doi: 10.1002/uog.18955. doi: 10.1002/uog.18955 pmid: 29134715
[23]	Mohr-Sasson A, Orvieto R, Blumenfeld S, et al. The association between follicle size and oocyte development as a function of final follicular maturation triggering[J]. Reprod Biomed Online, 2020, 40(6):887-893. doi: 10.1016/j.rbmo.2020.02.005. doi: S1472-6483(20)30093-6 pmid: 32389425
[24]	Sun Z, Song J, Zhang X, et al. SWATH(HM)-Based Metabolomics of Follicular Fluid in Patients Shows That Progesterone Adversely Affects Oocyte Quality[J]. Biomed Res Int, 2018, 2018:1780391. doi: 10.1155/2018/1780391. doi: 10.1155/2018/1780391
[25]	Zhang X, Wang T, Song J, et al. Study on follicular fluid metabolomics components at different ages based on lipid metabolism[J]. Reprod Biol Endocrinol, 2020, 18(1):42. doi: 10.1186/s12958-020-00599-8. doi: 10.1186/s12958-020-00599-8 URL
[26]	Luti S, Fiaschi T, Magherini F, et al. Relationship between the metabolic and lipid profile in follicular fluid of women undergoing in vitro fertilization[J]. Mol Reprod Dev, 2020, 87(9):986-997. doi: 10.1002/mrd.23415. doi: 10.1002/mrd.23415 URL
[27]	Zarezadeh R, Nouri M, Hamdi K, et al. Fatty acids of follicular fluid phospholipids and triglycerides display distinct association with IVF outcomes[J]. Reprod Biomed Online, 2021, 42(2):301-309. doi: 10.1016/j.rbmo.2020.09.024. doi: 10.1016/j.rbmo.2020.09.024 pmid: 33279420
[28]	Shibahara H, Ishiguro A, Inoue Y, et al. Mechanism of palmitic acid-induced deterioration of in vitro development of porcine oocytes and granulosa cells[J]. Theriogenology, 2020, 141:54-61. doi: 10.1016/j.theriogenology.2019.09.006. doi: S0093-691X(19)30388-7 pmid: 31518729
[29]	Itami N, Shirasuna K, Kuwayama T, et al. Palmitic acid induces ceramide accumulation, mitochondrial protein hyperacetylation, and mitochondrial dysfunction in porcine oocytes[J]. Biol Reprod, 2018, 98(5):644-653. doi: 10.1093/biolre/ioy023. doi: 10.1093/biolre/ioy023 URL
[30]	Sessions-Bresnahan DR, Schauer KL, Heuberger AL, et al. Effect of Obesity on the Preovulatory Follicle and Lipid Fingerprint of Equine Oocytes[J]. Biol Reprod, 2016, 94(1):15. doi: 10.1095/biolreprod.115.130187. doi: 10.1095/biolreprod.115.130187 pmid: 26632608
[31]	Song J, Wang X, Guo Y, et al. Novel high-coverage targeted metabolomics method (SWATHtoMRM) for exploring follicular fluid metabolome alterations in women with recurrent spontaneous abortion undergoing in vitro fertilization[J]. Sci Rep, 2019, 9(1):10873. doi: 10.1038/s41598-019-47370-7. doi: 10.1038/s41598-019-47370-7 URL
[32]	Fayezi S, Leroy J, Ghaffari Novin M, et al. Oleic acid in the modulation of oocyte and preimplantation embryo development[J]. Zygote, 2018, 26(1):1-13. doi: 10.1017/S0967199417000582. doi: 10.1017/S0967199417000582 URL
[33]	邢亚楠, 张勇, 黄娇娇, 等. 母马大、小卵泡的卵泡液代谢组学分析及其对卵泡发育的影响[J]. 中国畜牧杂志, 2019, 55(10):5-9. doi: CNKI:SUN:ZGXM.0.2019-10-002. doi: CNKI:SUN:ZGXM.0.2019-10-002
[34]	Neven A, Laven J, Teede HJ, et al. A Summary on Polycystic Ovary Syndrome: Diagnostic Criteria, Prevalence, Clinical Manifestations, and Management According to the Latest International Guidelines[J]. Semin Reprod Med, 2018, 36(1):5-12. doi: 10.1055/s-0038-1668085. doi: 10.1055/s-0038-1668085 URL
[35]	Yang Z, Zhou W, Zhou C, et al. Steroid metabolome profiling of follicular fluid in normo- and hyperandrogenic women with polycystic ovary syndrome[J]. J Steroid Biochem Mol Biol, 2021, 206:105806. doi: 10.1016/j.jsbmb.2020.105806. doi: 10.1016/j.jsbmb.2020.105806 URL
[36]	Sun Z, Chang HM, Wang A, et al. Identification of potential metabolic biomarkers of polycystic ovary syndrome in follicular fluid by SWATH mass spectrometry[J]. Reprod Biol Endocrinol, 2019, 17(1):45. doi: 10.1186/s12958-019-0490-y. doi: 10.1186/s12958-019-0490-y URL
[37]	Chen X, Lu T, Wang X, et al. Metabolic alterations associated with polycystic ovary syndrome: A UPLC Q-Exactive based metabolomic study[J]. Clin Chim Acta, 2020, 502:280-286. doi: 10.1016/j.cca.2019.11.016. doi: 10.1016/j.cca.2019.11.016 URL
[38]	Chen M, Zhang B, Cai S, et al. Metabolic disorder of amino acids, fatty acids and purines reflects the decreases in oocyte quality and potential in sows[J]. J Proteomics, 2019, 200:134-143. doi: 10.1016/j.jprot.2019.03.015. doi: 10.1016/j.jprot.2019.03.015 URL
[39]	Bai Y, Zhang F, Zhang H, et al. Follicular Fluid Metabolite Changes in Dairy Cows with Inactive Ovary Identified Using Untargeted Metabolomics[J]. Biomed Res Int, 2020, 2020:9837543. doi: 10.1155/2020/9837543. doi: 10.1155/2020/9837543