Abstract: Conventional IVF has been the main strategy as it facilitates the development of multiple follicles and reduce the cancel rate in ART applications. However, it was observed that conventional IVF had the change in oocyte quality, embryos quality and endometrial receptivity which had side effect on IVF outcome. Other problems of conventional IVF included OHSS, multiple pregnancies and high cost which affect patients' compliance. So the need for a large number of oocytes as an integral part of a successful IVF programme may be queried. And how to balance between safety and effectiveness is a difficult question of clinical ART. With the development of techniques and medicine, mild IVF lowered Gn dosage by simulating natural development of follicle and embryo. Mild IVF was characterized by easy and simple to handle, short duration of medical treatment, low cost, and low rates of OHSS and multiple pregnancies. Mild IVF with the acceptable pregnancy rate improved the clinical outcomes of babies. We reviewed the current knowledge about mild IVF, advantages and disadvantages of mild IVF in clinical practice.

Key words: Ovulation induction, Clinical protocols, Ovum, Blastocyst, Ovarian hyperstimulation syndrome, Congenital abnormalities