国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2011, Vol. 30 ›› Issue (2): 99-103.

• 综述 • 上一篇    下一篇

凋亡相关因子在早期胚胎发育中的作用机制

余 敏, 李 红, 全 松   

  1. 510515 广州，南方医科大学南方医院生殖医学中心
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2011-03-15 发布日期:2011-03-15
  • 通讯作者: 李 红

The Effect of Apoptosis?鄄related Factors on Early Embryonic Development

ＹU Min, LI Hong, QUAN Song   

  1. The Center for Reproductive Medicine, Department of Gynecology and Obstetrics, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2011-03-15 Online:2011-03-15
  • Contact: LI Hong

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摘要： 细胞凋亡与早期胚胎发育的关系密切，是导致胚胎发育停滞和辅助生殖技术（ART）失败的主要原因。抗凋亡因子在促进早期胚胎发育、提高胚胎质量和ART成功率等方面具有重要意义。综述细胞凋亡的分子调控机制及其诱导因素，以及调控凋亡基因表达的因子、生长因子、抗氧化剂、1?鄄磷酸鞘氨醇、瘦素、前列环素、骨桥蛋白和热休克蛋白等几种重要的抗凋亡因子在促进早期胚胎发育方面作用机制的研究进展。

关键词: 细胞凋亡, 凋亡抑制蛋白质类, 胚胎发育, 生殖技术, 辅助

Abstract: Apoptosis is closely related to early embryonic development. It is an major cause for arrest of embryonic development and failure of assisted reproductive technology（ART）. Anti?鄄apoptosis factors have very important significance in promoting early embryonic development, improving embryonic quality and increasing ART achievement rate. Now review the mechanism of molecule regulation of apoptosis, factors inducing apoptosis, and recent studies of several important anti?鄄apoptosis factors, such as factors regulating gene expression of apoptosis, growth factors, antioxidants, Sphingosine 1?鄄phosphate, leptin, prostacycline, osteopontin and heat shock protein, in promoting early embryonic development.

Key words: Apoptosis, Inhibitor of apoptosis proteins, Embryonic development, Reproductive techniques, assisted