国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2012, Vol. 31 ›› Issue (5): 408-412.

• 综述 • 上一篇    下一篇

女性血液系统恶性肿瘤的生殖保护策略

王磊,邵小光   

  1. 116033 辽宁省大连市妇产医院生殖中心
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2012-09-15 发布日期:2012-09-15

The Fertility Preservation for Female with Hematologic Malignant Tumor

WANG Lei，SHAO Xiao-guang   

  1. The Reproductive Center of Dalian Obstetric and Gynecology Hospital，Dalian 116033，Liaoning Province，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2012-09-15 Online:2012-09-15

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摘要： 血液系统恶性肿瘤是造血系统的恶性疾病，发病率在患恶性肿瘤的年轻人中居首位。化疗
是其早期治疗的主要手段，但这会对女性的卵巢结构和功能产生严重的甚至是不可逆的损害。因此，对于
患有血液系统恶性肿瘤的妇女，既要保护其卵巢的生殖功能，又不能影响其原发病的治疗效果。目前可能
有效的生殖保护手段是胚胎冷冻、卵子冷冻、卵巢及卵巢组织冷冻、卵巢移位、促性腺激素释放激素（GnRH）类似物、避孕药和激素疗法等。

关键词: 血液肿瘤, 抗肿瘤联合化疗方案, 低温保存, 促性腺素释放激素, 治疗

Abstract: Blood system malignant tumor isa group of malignant diseases with the highest incidence inyouth. For the early treatment，chemotherapy is of first choice. Chemotherapy will produce serious andirreversible damage for ovarian structure and function. So far the female with blood system malignant tumor, theprimary chemotherapy should be carried with consideration of the fertility preservation of ovary. At present，thepossible methods of effective fertility preservation are embryo cryopreservation，mature and immature oocytecryopreservation，ovarian and ovarian tissue cryopreservation，ovarian transplantation，GnRH -analogues usage，oral contraceptive，hormone replacement therapy and so on.

Key words: Hematologic neoplasms, Antineoplastic combined chemotherapy protocols, Cryopreservation, Gonadotropin-releasing hormone, Therapy