国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2013, Vol. 32 ›› Issue (6): 450-453.

• 综述 • 上一篇    下一篇

苯并芘的生殖毒性机制研究进展

连立芬, 陈亚琼, 侯海燕   

  1. 050000 石家庄，河北医科大学（连立芬）；天津市武警后勤学院附属医院妇产科（连立芬，陈亚琼，侯海燕）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2013-11-15 发布日期:2013-11-15
  • 通讯作者: 陈亚琼

Reproductive Toxicity of ■pyrene

LIAN Li-fen，CHEN Ya-qiong，HOU Hai-yan   

  1. Hebei Medical University，Shijiazhuang 050000，China（LIAN Li-fen）；Department of Obstetrics and Gynecology，Affiliated Hospital of the Chinese People′s Armed Forces Medical School，Tianjin 300162，China（LIAN Li-fen，CHEN Ya-qiong，HOU Hai-yan）
  • Received:1900-01-01 Revised:1900-01-01 Published:2013-11-15 Online:2013-11-15
  • Contact: CHEN Ya-qiong

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摘要： 多环芳烃是常见的空气污染物，主要来源于烟草烟雾、煤炭燃烧、汽车尾气和室内烹调油烟，易在水体、土壤和作物中残留蓄积。苯并（a）芘是多环芳烃中最具代表性的环境有机污染物。大量的流行病学调查和动物实验表明，苯并（a）芘与不良妊娠结局的发生有关，如生育能力下降、不孕不育、流产、早产、胎儿生长受限及胎儿出生缺陷等，其可能的作用机制包括影响细胞色素P450酶的代谢、改变细胞周期进程、参与DNA损伤及其抗雌激素效应等。

关键词: 苯并芘, 生殖, 氧化性应激, 细胞周期, DNA损伤, 内分泌干扰物

Abstract: Polycyclic aromatic hydrocarbons（PAHs）, a series of common air pollutants mainly from tobacco smoke，coal burning，vehicle exhaust and indoor cooking fumes， are easily accumulated in water，soil and crop. Benzo（a）pyrene（BaP） is the representative environmental organic pollutants of PAHs. A large number of epidemiological investigations and animal experiments showed that BaP was related to the adverse pregnancy outcomes，such as reduced fertility，infertility，miscarriage，premature birth，fetal growth restriction and fetal birth defects. The mechanisms of BaP effects could include the cytochrome P450 enzyme metabolism，cell cycle progression，DNA damage, and anti-estrogen effect.

Key words: Benzo（a）pyrene, Reproduction, Oxidative stress, Cell cycle, DNA damage, Endocrine disruptors