国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2016, Vol. 35 ›› Issue (1): 13-16.

• 论著 • 上一篇    下一篇

hCG日血清孕酮水平与直径≥14 mm卵泡数比值与IVF-ET

丁锦丽，杨菁，赵萌，张怡   

  1. 430060 武汉大学人民医院生殖医学中心
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2016-01-15 发布日期:2016-01-15
  • 通讯作者: 杨菁

Pregnancy Outcome of IVF-ET Related to the Progesterone-to-follicle Index on hCG Day

DING Jin-li，YANG Jing，ZHAO Meng，ZHANG Yi   

  1. Reproductive Medical Center，Renmin Hospital of Wuhan University，Wuhan 430060，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2016-01-15 Online:2016-01-15
  • Contact: YANG Jing

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摘要： 目的：评价人绒毛膜促性腺激素（human chorionic gonadotropin，hCG）日血清孕酮水平与B型超声（B超）下直径≥14 mm的卵泡数比值（progesterone-to-follicle index，PFI）与体外受精-胚胎移植（in vitro fertilization-embryo transfer，IVF-ET）治疗结局的关系。方法：回顾性分析2013年1月—2013年8月于我院行IVF助孕的384个IVF周期的患者资料，根据妊娠结局的不同分组比较组间hCG日孕酮、PFI等资料，再根据hCG日PFI将研究对象分为3组：PFI＜0.05为A组，0.05～0.10为B组，PFI≥0.10为C组，比较组间的一般资料和临床结局。结果：妊娠组hCG日孕酮水平以及PFI均低于对照组，差异有统计学意义（P＜0.05）；A、B组hCG日雌二醇（E2）水平均高于C组，差异有统计学意义（P＜0.05）；A组hCG日孕酮水平低于B、C组，且B组低于C组，差异均有统计学意义（P＜0.05）；A组的种植率高于C组，差异有统计学意义（P＜0.05）。结论：hCG日高PFI可能预测不良IVF-ET种植结局。

关键词: 孕酮, 卵泡, 种植结局

Abstract: Objective：To investigate the pregnancy outcomes of in vitro fertilization-embryo transfer （IVF-ET） related to the progesterone-to-follicle index（ＰＦＩ）, which is the ratio of serum progesterone level to the number of follicle with diameter≥14 mm on the day of hCG administration in IVF cycles. Methods：A retrospective analysis was performed on the data of 384 IVF cycles between January 2013 and August 2013. The level of progesterone and PFI were compared between pregnancy patients and non-pregnancy patients. 384 cycles were divided into three groups according to PFI, group A with PFI＜0.05, group B with PFI 0.05-0.10, and group C with PFI≥0.10. The basic information and pregnancy outcome were analyzed. Results：The level of progesterone and PFI in the pregnant group were significantly lower than those in the non-pregnant group （Ｐ＜０．０５）. The levels of estradiol in the group A and the group B were significantly higher than that in the group C （Ｐ＜０．０５）. The level of progesterone in the group A was significantly lower than those in the group B and the group C, while the level of progesterone in the group B was significantly lower than that in the group C （Ｐ＜０．０５）. The implantation rate in the group A was significantly higher than that in the group C （Ｐ＜０．０５）. Conclusions：The higher PFI on the hCG day may predict adverse implantation outcome of IVF-ET.

Key words: Progesterone, Ovarian follicle, Implantation outcome