关键词: 心血管畸形, 植入前诊断, 生殖技术, 辅助, 单基因病, 遗传阻断

Abstract: Many hereditary cardiovascular diseases with a high risk of sudden death seriously affect the life quality of patients. Those hereditary cardiovascular diseases caused by single gene defect can be classified into monogenic cardiovascular diseases and monogenic syndromic diseases with cardiovascular abnormalities, according to whether multiple organ defects are involved. Pre-implantation genetic diagnosis (PGD) technology can be used to select the embryos that do not carry the genetic defect for implantation so as to block the monogenic diseases. With the continuous improvement of technology, PGD has been applied to more and more hereditary cardiovascular disorders.

Key words: Cardiovascular abnormalities, Preimplantation diagnosis, Reproductive techniques, assisted, Monogenic disease, Genetic interruption