国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2020, Vol. 39 ›› Issue (4): 284-286.

• 论著 • 上一篇    下一篇

宫颈锥切术后患者行体外受精-胚胎移植后的妊娠结局分析

王培，丁卉，凌秀凤，赵纯，谢奇君，李秀玲   

  1. 210004  南京医科大学附属妇产医院（南京市妇幼保健院）生殖中心
  • 收稿日期:2020-03-06 修回日期:2020-04-19 出版日期:2020-07-15 发布日期:2020-07-15
  • 通讯作者: 李秀玲，E-mail：njlxl@qq.com E-mail:njlxl@qq.com
  • 基金资助:
    国家自然科学基金（81971386）

Analysis of Pregnancy Outcome of In Vitro Fertilization and Embryo Transfer in Patients after Cervical Conization

WANG Pei，DING Hui，LING Xiu-feng，ZHAO Chun，XIE Qi-jun，LI Xiu-ling   

  1. Reproductive Center，Women′s Hospital of Nanjing Medical University（Nanjing Maternity and Child Health Care Hospital），Nanjing 210004，China
  • Received:2020-03-06 Revised:2020-04-19 Published:2020-07-15 Online:2020-07-15
  • Contact: LI Xiu-ling，E-mail: njlxl@qq.com E-mail:njlxl@qq.com

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摘要： 目的：探讨宫颈锥切术对不孕症患者行体外受精-胚胎移植（IVF-ET）治疗后妊娠结局的影响。方法：选取2013年1月—2019年12月行IVF-ET治疗的有宫颈锥切术史的不孕症患者共35例作为研究组，随机选取同期在本中心行IVF-ET治疗的无宫颈锥切术史、宫颈刮片结果为正常或炎症的不孕症患者98例作为对照组。对2组患者的妊娠早期指标和单胎分娩患者的分娩结局进行分析。结果：2组患者的年龄、不孕时间、孕次、产次、不孕因素比较差异无统计学意义（P＞0.05）。2组患者的流产率、早期流产率比较差异均无统计学意义（P＞0.05）；研究组宫颈环扎率高于对照组（P=0.001）。2组患者中单胎分娩者的足月产率、早产率、分娩孕周、剖宫产率、低出生体质量儿发生率差异无统计学意义（均P＞0.05）；研究组新生儿出生体质量低于对照组，差异有统计学意义（P=0.048）。结论：宫颈锥切术史对不孕症患者IVF-ET术后的妊娠结局无显著影响，可以通过移植单个胚胎、妊娠早期检查宫颈机能和孕期控制体质量来减少产科并发症的发生，获得较好的妊娠结局。

关键词: 宫颈锥切术；, 生殖技术, 辅助；, 体外受精；, 胚胎移植；, 妊娠结局

Abstract: Objective: To investigate the effect of cervical conization on the pregnancy outcome of in vitro fertilization and embryo transfer (IVF-ET) in patients with infertility. Methods：A total of 35 infertile patients with a history of cervical conization who treated with IVF-ET from January 2013 to December 2019 were selected as the case group, and 98 infertile patients without history of cervical conization and with the results of normal or inflammatory cervical curettage who treated with IVF-ET in the same period were randomly selected as the control group. The index of early pregnancy and the delivery outcome of singleton delivery were compared between the two groups. Results：There were no significant differences in age, years of infertility, times of pregnancy, parity and factors of infertility between the two groups (P＞0.05). There was no significant differences in the abortion rate and early abortion rate between the two groups (P＞0.05), but the cervical ligature rate in the study group was higher than that in the control group (P=0.001). There were no significant differences in term delivery, premature delivery, gestational age, cesarean section and low birth weight between the two groups (all P＞0.05), but the birth weight of newborns in the study group was significantly lower than that in the control group (P=0.048). Conclusions：The history of cervical conization has no significant effect on the pregnancy outcome of infertile patients undergoing IVF-ET. We can reduce the occurrence of obstetrical complications and obtain better pregnancy outcome by transferring single embryo, checking cervical function in early pregnancy and controlling body weight during pregnancy.

Key words: Conization of cervix uteri;, Reproductive techniques, assisted, Fertilization in vitro;, Embryo transfer;, Pregnancy outcome